The progression of a normal cell to senescence in vivo and in vitro is accompanied by a reduction in the length of the telomeres, the chromosome capping segments at the end of each linkage group. However, overexpression of the reverse transcriptase subunit (HTERT) of the ribonucleoprotein telomerase restores telomere length and delays cellular senescence. Although some data exist in the literat...

As compared to conventional photon radiation heavy ions may offer specific therapeutic advantages in radiation oncology with respect to the higher relative biological effectiveness (RBE) at beam terminus. It has been demonstrated for heavy ion irradiation that the RBE in irradiated normal tissue, especially for acute effects is only slightly increased. However, since normal tissue reactivity, i...

The human fibroblast activation protein (FAP), defined by monoclonal antibody F19, is expressed in vivo in reactive stromal fibroblasts of epi thelial cancers, subsets of bone and soft tissue sarcomas, and granulation tissue of healing wounds. FAP is generally absent from the stroma of benign epithelial tumors and normal adult tissues. In vitro FAP induction is observed in proliferating culture...

The human fibroblast activation protein (FAP), defined by monoclonal antibody F19, is expressed in vivo in reactive stromal fibroblasts of epi thelial cancers, subsets of bone and soft tissue sarcomas, and granulation tissue of healing wounds. FAP is generally absent from the stroma of benign epithelial tumors and normal adult tissues. In vitro FAP induction is observed in proliferating culture...

The human fibroblast activation protein (FAP), defined by monoclonal antibody F19, is expressed in vivo in reactive stromal fibroblasts of epithelial cancers, subsets of bone and soft tissue sarcomas, and granulation tissue of healing wounds. FAP is generally absent from the stroma of benign epithelial tumors and normal adult tissues. In vitro FAP induction is observed in proliferating cultured...

The aim of this study was to investigate the antioxidant properties root extract Onosma armeniacum and its cytotoxic effect against human liver (HepG2), lung (A549) colon (WiDr) cancer cell lines compared with a normal fibroblast line. Antioxidant determined using colorimetric methods. were investigated MTT assay. total phenolic content reducing power values 26.1±0.4 mg gallic acid equivalent 5...