Nomifensine, an antidepressant agent, competitively inhibits dopamine uptake in the caudate-putamen and nucleus accumbens and binds to both dopaminergic and noradrenergic reuptake sites in the striatum and thalamus. In this study the effect of nomifensine on anacoccygeus contraction induced by noradrenaline and electrical stimulation was investigated in rats and compared to the effect of phen...

objective: to determine the effects of ramadan fasting on serum levels of stress neurohormones in iranian women with polycystic ovary syndrome (pcos). materials and methods: this study was a clinical trial and was performed during july 2011 (month of ramadan) in royan institute, tehran. a total of 40 women who were aged 20-40 years and known cases of pcos and had no other medical diseases were ...

We have recently shown that methylenedioxymethamphetamine (MDMA), methylenedioxyamphetamine (MDA), cathinone and methylenedioxyethylamphetamine (MDEA) have a cocaine-like action to potentiate the contractile actions of noradrenaline but not isoprenaline in the 1-Hz paced rat right ventricle. The purpose of this study was to directly test the actions of these compounds at the noradrenaline trans...

1. Isolated hind limbs of rats were perfused and vascular smooth muscle sensitivity to noradrenaline, methoxamine and potassium chloride was measured and dose-response curves were obtained. 2. The sensitivity of vascular smooth muscle to noradrenaline is attenuated by adrenalectomy and low sodium diet; it is enhanced by corticosterone. High sodium diet or administration of deoxycorticosterone d...

The human neuroblastoma clone SH-SY5Y expresses potassium-, carbachol-, and calcium ionophore A23187-evoked, calcium-dependent release of [3H]noradrenaline. Release in response to carbachol and potassium was greater than additive. Atropine (Ki = 0.33 nM), hexahydrosiladifenidol (Ki = 18 nM), and pirenzepine (Ki = 1,183 nM) completely inhibited the carbachol-evoked noradrenaline release, an orde...

1. Plasma noradrenaline concentrations were similar in normotensive and hypertensive outpatients, but were significantly lower in laboratory control subjects. 2. Standing plasma noradrenaline concentrations were similar in all three groups. 3. Urinary vanillyl mandelic acid, catecholamines and metanephrines were also similar in the normotensive and hypertensive groups. 4. Laboratory controls, p...

The effects of noradrenaline on membrane resistance of smooth muscle cells of the guinea-pig main pulmonary artery were assessed from the change in amplitude of electronic potentials produced by extracellularly applied current pulses. Noradrenaline was applied exogenously by bath application or endogenously by stimulating perivascular nerves. Exogenous noradrenaline depolarized the smooth muscl...

This contribution is an overview on the role of noradrenaline as neurotransmitter and stress hormone in emotional memory processing. The role of stress hormones in memory formation of healthy subjects can bear significance for the derailment of memory processes, for example, in post traumatic stress disorder (PTSD). Increased noradrenaline levels lead to better memory performance, whereas block...

BACKGROUND There is increasing evidence that neuropeptide Y (NPY) contributes to the autonomic control of the circulation. NPY coexists with noradrenaline in perivascular nerve terminals, may be released during sympathetic stimulation, and is a potent constrictor of the human coronary circulation and other vascular beds. In vitro studies show that NPY can act either directly on vascular smooth ...

1. The effect of infusion of noradrenaline (0.42 mumol min-1 kg-1) on the exchange of nonesterified fatty acids, glycerol and other metabolites across subcutaneous abdominal adipose tissue was investigated in five healthy subjects using an arteriovenous catheterization technique and measurement of adipose tissue blood flow using the 133Xe clearance technique. At the same time, the net rate of f...