The swimming endurance test, anoxic tolerance and basal activity by actophotometer were used to assess the antistress of a seven-day therapy (200 400 mg/kg, p.o.) ethanolic extract Coriandrum sativum (EECS) aerial parts. A method for measuring in vitro antioxidant hydroxyl radicals was used. In all examined models, at both doses demonstrated effects. duration stay on rotarod, EECS treated rats ...

Dementia is a syndrome usually occur Alzheimer’s disease (AD) and vascular dementia (VD) due to disease in brain. It associate’s the impairment of memory, thinking, learning disability, orientation and judgement. These changes effects on cognition functions to decline earlier function of learning and memory. Since, the drugs and natural remedies have been prescribed to enhance the memory and pr...

Effects of aniracetam on whole-cell calcium currents were studied in acutely isolated neuronal cells from postnatal rat ventromedial hypothalamus. There were three types of inward calcium currents, one low-threshold transient current and two high-threshold sustained currents. The nicardipine sensitive L-type current was activated at -20 mV or more depolarized potentials, and the omega-conotoxin...

Piracetam, a derivative of γ-aminobutyric acid, exerts memory-enhancing and mild anxiolytic effects in human and rodent studies. To examine the drug's behavioral profile further, we assessed its effects on behavioral and endocrine (cortisol) responses of adult zebrafish (Danio rerio)--a novel model species rapidly gaining popularity in neurobehavioral research. Overall, acute piracetam did not ...

Subchronic administration of BR-16A (Mentat), a compound herbal formulation, and the nootropic agent, piracetam, augmented learning acquisition and retention of learning in normal rats, as well as in states of cognitive deficits induced by prenatal undernutrition, postnatal environment impoverishment and sodium nitrite hypoxia. The test paradigms used were step-down latency in a passive avoidan...

Nootropic acitivity of calyces of Hibiscus sabdariffa Linn. was studied in mice. Elevated plus maze and passive avoidance paradigm were employed to evaluate learning and memory parameters. Scopolamine (0.4 mg/kg, i.p.) was used to induce amnesia in mice. The aqueous extracts of calyces of Hibiscus sabdariffa (HS-100 and 200 mg/kg, p.o.) significantly attenuated amnestic deficits induced by scop...

Levetiracetam, the alpha-ethyl analogue of the nootropic piracetam, is a widely used antiepileptic drug (AED) that provides protection against partial seizures and is also effective in the treatment of primary generalized seizure syndromes including juvenile myoclonic epilepsy. Levetiracetam was discovered in 1992 through screening in audiogenic seizure susceptible mice and, 3 years later, was ...