Xenoestrogens, such as bisphenol A and diethylstilbestrol, are glucuronidated by an isoform of UDP-glucuronosyltransferase named UGT2B1 in the livers of adult male rats. In this study, we found that nonylphenol and octylphenol are also conjugated with glucuronic acid by adult rat liver microsomes. Although UDP-glucuronosyltransferase activities toward these xenoestrogens were not detected in th...

PURPOSE A case control study was conducted to assess the effects of long-term ingestion of Topiramate on fertility, body and reproductive organ weight and level of sex hormones in Sprague-Dawley male rats. METHODS Ten adult male rats were exposed to Topiramate diets at a concentration of 100 mg /kg for 60 days. Another ten control male rats received vehicle (distilled water). After 24 hours o...

the purpose of this study was to evaluate the probable effects of the vitamin e addition in different levels to the extender of chicken semen on spermatozoa quality during storage of semen at 4°c for 0, 3, 6, 10 and 24 hours. eight young ross broiler breeder strain 308 roosters were used in this experiment. the collected semen from all roosters was mixed together and diluted with modified a rin...

The objective of present study was to investigate the effects of aqueous garlic extracts, vitamin E and N-acetylcysteine on lead-induced lipid peroxidation, changes in antioxidant defense system and semen quality in the rat testes. Twenty-five male rats were divided into five groups. Animals within different treatment groups were maintained on their respective diets for 35 days as follows: grou...

Cimetidine is effective drugs on male reproductive system by its effect semen characteristic or parameters such as sperm motility, morphology and count, also cimetidine sexual hormones, were testosterone, FSH LH. In this investigation, 20 rats randomly classified into two groups, Control group(G1): This group contain 10 receiving normal saline group( G2): 100mg/kg. B.W. from group, during the p...

BACKGROUND The sperm chromatin structure assay (SCSA) provides an objective assessment of sperm chromatin integrity, which is essential for normal sperm function. SCSA is valuable as a fertility marker in epidemiological studies and in the clinical situation. Little is known about the impact of testicular and post-testicular function on SCSA parameters. METHODS Ejaculates from 278 military co...

BACKGROUND Reproductive toxicity of Atrazine (ATR) was evaluated in two rat multigenerational studies. Development of male reproductive parameters was evaluated in separate studies after prenatal or postnatal exposure. METHODS In multigenerational studies, rats received dietary concentrations of 0, 10, 50, 100 or 500 ppm ATR. In separate studies in female rats, ATR was administered by gavage ...

Objective: Age brings about changes to the oxidant and antioxidant balance of male testis that give rise loss fertility. The Ferula elaeochytris root extract (FE), contents anti-inflammatory component, have been used treat infertility by local people for centuries. main objectives this study were determine whether FE was effective on sperm quality, spermatogenesis, apoptosis oxidative stress in...

Objective- Release of free radicals and oxidants following increased temperature of testis in cryptorchidism, play an important role in the producing testicular damage. The present study investigated the role of vitamin C as an antioxidant in protecting the testis against damage in experimental unilateral cryptorchidism. Design- Experimental study Animals- Forty five male adult Wistar–Albino ...

Nonylphenol (NP), an estrogen like compound classified as an endocrine disrupter capably interfering hormonal system of numerous organisms, originates principally from the degradation of nonylphenol ethoxylates (NE) widely used in industrial, agricultural, commercial and household applications as detergents, emulsifiers, wetting and dispersing agents. Due to the extensive use of NE, NP may reac...