Dyspepsia is common in the general population, and despite a paucity of data, smoking, alcohol, and analgesics are believed to be important risk factors. The role of these environmental factors in subjects with uninvestigated dyspepsia was evaluated in a representative population sample. An age and gender stratified random sample of residents of Olmsted County, Minnesota, aged 20 to 64 years wa...

Background: Traditionally some people employ Ocimum basilicum (Shaspram) to relieve the symptoms of dyspepsia. We therefore studied the effects of oral extract of this medicinal plant on functional dyspepsia. Methods: In a double-blind placebo-controlled clinical trial, the effect of a four-week treatment of Shaspram was evaluated on functional dyspepsia. Two hundred cases from all patients ref...

BACKGROUND Helicobacter pylori (H pylori) is the main cause of peptic ulcer disease. The role of H pylori in non-ulcer dyspepsia is less clear. OBJECTIVES To determine the effect of H pylori eradication on dyspepsia symptoms and quality of life scores in patients with non-ulcer dyspepsia. SEARCH STRATEGY Trials were identified through electronic searches of the Cochrane Controlled Trials Re...

The prevalence of sleep disturbances was studied in patients with severe non-ulcer dyspepsia. It was also considered if the change in sleep pattern was associated with changes in the rhythmic fasting motor activity of the gastrointestinal tract, and if motor events correlate with the patient's symptoms. Motor activity in the duodenum was monitored over a 24 hour period under freely ambulatory c...

Dyspepsia is a common condition in the general population but data are lacking on the benefits of effective acid inhibition with proton pump inhibitors in functional dyspepsia. The results of the large, randomised, double blind clinical trials, BOND and OPERA, the Scandinavian PILOT study, and a follow up study, ENCORE, are reviewed. BOND, OPERA, and PILOT aimed to address the question of wheth...

Dyspepsia is a common condition in the general population but data are lacking on the benefits of effective acid inhibition with proton pump inhibitors in functional dyspepsia. The results of the large, randomised, double blind clinical trials, BOND and OPERA, the Scandinavian PILOT study, and a follow up study, ENCORE, are reviewed. BOND, OPERA, and PILOT aimed to address the question of wheth...

BACKGROUND The health-related quality of life is impaired in patients with functional gastrointestinal disorders seen in referral centres. AIM To determine whether the health-related quality of life is impaired in subjects with functional disorders in the community and whether any differences can be explained by psychological co-morbidity. METHODS In a population-based, nested, case-control...

BACKGROUND Dyspepsia is a common disorder that can present many clinical dilemmas in patient management. Although not life-threatening, the symptoms are long-lasting, interfere with daily activities and have a significant impact upon quality of life. The aim of this study was to determine prevalence of dyspepsia and its relationship with demographic and socioeconomic factors, and lifestyle in a...

OBJECTIVE To explore patient factors related to the use of prescribed and non-prescribed drugs for dyspepsia in The Netherlands. DESIGN Patient survey study. SETTING AND SUBJECTS Questionnaires sent to patients who had a prescription for dyspepsia medication from their general practitioner. MAIN OUTCOME MEASURES Patient factors related to the on-demand use of prescribed medication and the...

Dyspepsia refers to a condition of impaired digestion which has a yearly incidence of approximately 1%, and the prevalence of around 20-30%. Although the etiology of dyspepsia varies, an organic cause is found in only 40% of the patients. In the differential diagnosis of dyspepsia, cardiac, hepatobiliary, pancreatic, and intestinal disorders and gastroesophageal reflux disease can be eliminated...