Background: Diabetes may cause a wide range of eye disorders, including cataracts, glaucoma and other ocular abnormalities, recurrent styes, non-arteritic anterior ischemic optic neuropathy diabetic papillopathy.

PURPOSE Focal neurodegeneration of the optic nerve in Leber hereditary optic neuropathy (LHON) is primarily due to a maternally inherited mitochondrial DNA mutation. However, the markedly reduced penetrance of LHON and segregation pattern of visual failure within families implicates an interacting nuclear genetic locus modulating the phenotype. Folate deficiency is known to cause bilateral opti...

OBJECTIVE To describe visual acuity outcomes of patients in the Ischemic Optic Neuropathy Decompression Trial (IONDT) after 24 months of follow-up. DESIGN The IONDT is a single-masked, multicenter, randomized clinical trial. SETTINGS Patients were evaluated and followed up at 25 clinical centers located throughout the United States. Data were sent to and analyzed at a central coordinating c...

purpose: to evaluate the role of transvitreal optic neurotomy (ton) in the management of non-arteritic anterior ischemic optic neurotomy (naion). methods: sixteen eyes of 16 patients with recent onset naion (less than six weeks duration) were included in this single-masked randomized controlled trial. the patients were randomized to ton (8 eyes) versus observation alone (8 eyes). pre- and posto...

Purpose: To evaluate the diagnostic value of retinal nerve fiber layer-to-disc ratio (RDR) compared to established parameters including layer thickness (RNFLT), Bruch membrane opening-minimum rim width (BMO-MRW), and area (BMO-MRA) for differentiating between open angle glaucoma (OAG) nonarteritic anterior ischemic optic neuropathy (NAION).Methods: This retrospective study included 23 disc size...

Objective: To report a case of Pseudo-Foster Kennedy (PFK) syndrome and describe its clinical and paraclinical particularities, as well as the diagnostic difficulties and established treatment. Methods: The case of a 60-year-old male patient with sudden, painless visual impairment in the left eye (LE), and a medical history of old optic nerve atrophy in his right eye (RE) was described. Results...