Background: Fatty liver (FL) is the most common liver disease but its clinical significance remains elusive. Nonalcoholic steatohepatitis (NASH) is increasingly recognized as a cause of liver failure, sometimes recurring following transplantation. Recent data on both conditions are critically reviewed. Methods: A Medline search of the medical literature (1990 to September 1998) and cross-refere...

Hepatic steatosis is defined as intrahepatic fat of at least 5% of liver weight. Simple accumulation of triacylglycerols in the liver could be hepatoprotective; however, prolonged hepatic lipid storage may lead to liver metabolic dysfunction, inflammation, and advanced forms of nonalcoholic fatty liver disease. Nonalcoholic hepatic steatosis is associated with obesity, type 2 diabetes, and dysl...

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are the leading causes of hepatic fibrosis liver-related mortality worldwide, despite efficient hepatitis B C antiviral therapies that have dramatically lowered load. Although significant efforts been exerted to understand molecular basis pathogenesis, there currently few therapeutic alternatives available for NAFL...

227 Received December 13, 2010; revision accepted for publication February 16, 2011. doi: 10.1620/tjem.223.227 Correspondence: Goh Eun Chung, M.D., Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, 39FL., Gangnam Finance Center 737, Yeoksam-Dong, Gangnam-Gu, Seoul 135-984, Korea. e-mail: [email protected] Elevated P...

Excess collagen synthesis (fibrogenesis) in the liver plays a causal role in the progression of nonalcoholic fatty liver disease (NAFLD). Methods are needed to identify patients with more rapidly progressing disease and to demonstrate early response to treatment. We describe here a novel method to quantify hepatic fibrogenesis flux rates both directly in liver tissue and noninvasively in blood....

Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease in the Western countries, affecting up to 25% of the general population and becoming a major health concern in both adults and children. NAFLD encompasses the entire spectrum of fatty liver disease in individuals without significant alcohol consumption, ranging from nonalcoholic fatty liver (NAFL) to nonal...

The deposition of fat in the hepatic tissue has been recognized long ago, in the early 1900s. In 1907, Hartley made the first accurate description of the fatty liver [1]. First regarded as a consequence of alcohol intake, Ludwig has observed its occurrence among non alcohol consumers in 1980, along with some of its potential harmful effects, especially the nonalcoholic steatohepatitis (NASH). S...

Nonalcoholic fatty liver disease is one of the most common hepatic disorders worldwide. Given the high-calorie nutrition of children and adults, nonalcoholic fatty liver disease (NAFLD) is expected to become a major cause of cirrhosis and eventually liver transplantation. Familial clustering and ethnic differences indicate that genetic factors contribute to NAFLD. Recently, the common variant p...