In this work we synthesized Nano hydroxyapatite (HAp) by Sol-gel method, Then we functionalized hydroxyapatite nanoparticle by use of 3-Aminopropyl trimethoxysilane (APTMS) , to improve the loading and control release of sulfasalazine drug bonded to APTMS. The drug release patterns from Sulfasalazine loaded HAp nanoparticles at pH value 8 For 6h, Sulfasalazine loaded functionalized HAp nanopa...