INTRODUCTION In the past several decades, declining incidences of nasopharyngeal carcinoma (NPC) have been observed in Chinese populations in Hong Kong, Taiwan, Los Angeles, and Singapore. A previous study indicated that the incidence of NPC in Sihui County, South China remained stable until 2002, but whether age, diagnosis period, and birth cohort affect the incidence of NPC remains unknown. ...

Nasopharyngeal carcinoma (NPC) is a malignant tumor of the head and neck region, which frequently occurs in Southeast Asia, especially in the south of China. It is known that the mammalian target of rapamycin (mTOR) pathway plays a central role in regulating cellular functions, including proliferation, growth, survival, mobility, and angiogenesis. Aberrant expression of the mTOR signaling pathw...

This study evaluated the efficacy, safety, and quality of life (QoL) measure of transdermal fentanyl (TDF) for moderate-to-severe pain due to oral mucositis caused by chemoradiotherapy in patients with advanced nasopharyngeal carcinoma (NPC). Patients with NPC who experienced moderate-to-severe oral mucosal pain during chemoradiotherapy (n = 78) received TDF for pain relief. Pain relief and QoL...

Sir William Osler, the first physician-in-chief of the Johns Hopkins Hospital and later Regius Professor of Medicine at Oxford, is judged by many to be the greatest clinician of the modern era. His life history of distinguished service to medicine and to society is well known. What is not so well known is his mischievous streak.

Claudins are a family of proteins that are structural and functional components of tight junctions and have crucial roles in the maintenance of cellular arrangement, adhesion and paracellular transport. Recent studies have shown that changes and/or loss of claudin expression plays an important role in tumorigenesis and tumor progression, and altered expression of claudins has been reported in v...

this commentary follows up on an editorial by eyal and colleagues in which these authors discuss the implications of the emergence of non-physician clinicians (npcs) on the health labour market for the education of medical doctors. we generally agree with those authors and we want to stress the importance of clarifying the terminology to describe these practitioners and of defining more formall...

how to cite this article: shalbafan b. a family case report of niemman pick c with new mutation and different presentations. iran j child neurol. 2015 autumn;9:4(suppl.1): 20-21.   pls see pdf.

Since the dawn of human civilization here on Earth, health has always been a major evolutional concern. For as long as people realized that every human need calls for a profession to fulfill, there has been a constant requirement for health care providers. Throughout the history of medicine, it was usually the physician as a case given alone held responsible for the patient’s health. With time ...

Nasopharyngeal carcinoma (NPC) has a highly increased incidence rate (20/100,000) in Southern regions of China, while being rare in the rest of the world. NPC is a malignant type of cancer due to its high occurrence rate of metastasis; however, biomarkers for effective diagnosis and treatment are yet to be identified. Annexin A1 is a glucocorticoid‑regulated member of a large superfamily of cal...