Recordings were made from single SI cortical neurons in the anesthetized macaque monkey. Each isolated cortical neuron was tested for responses to a standard series of mechanical stimuli. The stimuli included brushing the skin, pressure, and pinch. The majority of cortical neurons responded with the greatest discharge frequency to brushing the receptive field, but neurons were found in areas 3b...

Painful diabetic neuropathy is a common complication of diabetes mellitus and can affect many aspects of life and severely limit patients' daily functions. Signals of painful diabetic neuropathy are believed to originate in the peripheral nervous system. However, its peripheral mechanism of hyperalgesia has remained elusive. Numerous studies have accumulated that polymodal nociceptive C-fibres ...

Background and Objective: Due to the presence of some evidence for anti-diabetic and antioxidant activity of Tribulus terrestris (TT), this study was designed to investigate the anti-nociceptive effect of TT in streptozotocin-diabetic rats using formalin test and hot tail immersion tests. Materials and Methods: Rats were divided into control, TT-treated control, diabetic, sodium salicylate (SS)...

Introduction: Regulators of G-protein signaling protein negatively control G protein -coupled receptor signaling duration by accelerating Gα subunit guanosine triphosphate hydrolysis. Since regulator of G-protein signaling4 has an important role in modulating morphine effects at the cellular level and the exact mechanism(s) of adrenalectomy-induced morphine sensitization have not been fully cl...

C-tactile (CT) fibers, a population of unmyelinated (C) fibers that respond particularly well to gentle stroking, are widely believed subserve affective touch. However, these (termed C low-threshold mechanoreceptors (C-LTMRs) in non-human mammals) have also been proposed be involved the modulation pain. Intriguingly, functional evidence from both human and animal studies indicates CT/C-LTMR can...

As an important receptor located in the skin, a nociceptor is capable of detecting noxious stimuli and sending warning signals to central nervous system avoid tissue damage, thus inspiring development artificial nociceptors for electronic receptors. Recently, memristors have attracted increasing attention developing due simplicity nociceptive system. However, realization with biocompatibility b...

We made simultaneous bilateral recordings of unit activity in the n. 9 ventroposterior lateralis (VPL) in intact rats, and after acute and chronic left thoracic 10 hemisection. We observed an immediate bilateral decline in multireceptive units, 11 reflecting a loss of nociceptive input on the lesion side and a loss of low threshold 12 inputs contralaterally. Unit properties were restored to nor...

This study examines the effect of normal aging on temporal summation (TS) of pain and the nociceptive flexion reflex (RIII). Two groups of healthy volunteers, young and elderly, received transcutaneous electrical stimulation applied to the right sural nerve to assess pain and the nociceptive flexion reflex (RIII-reflex). Stimulus intensity was adjusted individually to 120% of RIII-reflex thresh...

Animals employ mechano-sensory systems to detect and explore their environment. Mechano-sensation encompasses stimuli such as constant pressure, surface movement or vibrations at various intensities that need to be segregated in the central nervous system. Besides different receptor structures, sensory filtering via intrinsic response properties could provide a convenient way to solve this prob...

Possible modulation of the Brewer's yeast-induced peripheral inflammation by two central neuropeptides, bradykinin and substance P (SP), was investigated in rats. Centrally administered bradykinin significantly increased pedal oedema and pain threshold whereas, SP produced significant augmentation of oedema volume and nociception. The results of the present study indicate that central bradykini...