نتایج جستجو برای: noael
تعداد نتایج: 385 فیلتر نتایج به سال:
Interest is increasing in the development of non-animal methods for toxicological evaluations. These methods are however, particularly challenging for complex toxicological endpoints such as repeated dose toxicity. European Legislation, e.g., the European Union's Cosmetic Directive and REACH, demands the use of alternative methods. Frameworks, such as the Read-across Assessment Framework or the...
This study characterizes aminoindole molecules that are analogs of Genz-644442. Genz-644442 was identified as a hit in a screen of ~70,000 compounds in the Broad Institute's small-molecule library and the ICCB-L compound collection at Harvard Medical School. Genz-644442 is a potent inhibitor of Plasmodium falciparum in vitro (50% inhibitory concentrations [IC₅₀s], 200 to 285 nM) and inhibits P....
Exposure to high concentrations of carbon black (Cb) produces lung tumors in rats, but not mice or hamsters, presumably due to secondary genotoxic mechanisms involving persistent lung inflammation and injury. We hypothesized that the lung inflammation and injury induced by subchronic inhalation of Cb are more pronounced in rats than in mice and hamsters. Particle retention kinetics, inflammatio...
Abstract Maleic acid polymer scale inhibitor is a new domestic seawater desalination inhibitor. This study tested the acute oral toxicity, sub-chronic toxicity and genotoxicity of this The LD 50 obtained from test was 6810 9260 mg/kg·BW for male female rats, as well 1/5, 1/10 1/20 were dose test. It showed weight rats with high significantly lower than control group during exposure period ( p &...
Abstract In South Korea, it has been found that biocides used to control and eliminate harmful organisms are as humidifier disinfectants cause lung disease in users. Hence, efforts have focused on studying the toxicity of workers who handle them. The purpose this study was evaluate effects inhalation exposure sodium dichloroisocyanurate (NaDCC) protect health handling NaDCC. F344 rats were expo...
T-2 toxin (T-2) was administered to adult Pannon White (n = 10/group) male rabbits for 65 days, first in a suspension by gavage (0.05, 0.1 or 0.2 mg/animal/day), and secondly mixed into the feed (0.33 and 0.66 mg/kg feed). In the first experiment 0.1 mg T-2 exposure resulted in temporary decrease in feed intake, slower increase in the gonadotropin-releasing hormone (GnRH) induced testosterone s...
CONTEXT Glycoside-based standardized fenugreek seed extract (SFSE-G) demonstrated promising efficacy in animal models of immune-inflammatory conditions. AIM The present study was aimed at embryo-fetal development toxicity evaluation of SFSE-G in Wistar rats as per guideline No. 414 of the Organization for Economic Co-operation and Development (OECD). MATERIAL AND METHODS Mated female rats w...
Haloacetonitriles are by-products of water chlorination and may form in vivo from the reaction of residual chlorine with endogenous compounds such as amino acids. Dibromoacetonitrile (DBAN) was negative in selected mutagenic assays; dichloroacetonitrile (DCAN) was mutagenic in S. typhimurium, but not in S. cerevisiae. Both DBAN and DCAN may be carcinogenic. There is a paucity of basic toxicolog...
• To describe the process of setting Guideline Values for inorganic parameters and describe the narrow divide between toxic and essential elements. • To describe some basic physico-chemical characteristics of water. • To provide some examples of inorganic chemicals to illustrate the uses of GVs for inorganics and highlight priority substances. • To describe the basis of monitoring of physical a...
Methylmercury is a neurotoxin at high exposures, and the developing fetus is particularly susceptible. Because exposure to methylmercury is primarily through fish, concern has been expressed that the consumption of fish by pregnant women could adversely affect their fetuses. The reference dose for methylmercury established by the U.S. Environmental Protection Agency was based on a benchmark ana...
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