Subarachnoid hemorrhage (SAH) usually results from ruptured aneurysm, but how leaked hemoglobin regulates the microcirculation in the pathophysiology of early brain injury after SAH is still unclear. In the present study, we sought to investigate the role and possible mechanism of hemoglobin induced pericyte phenotype transformation in the regulation of microcirculation after SAH. Endovascular ...

PURPOSE The nitric oxide (NO)-cyclic guanosine-3',5'-monophosphate (cGMP) pathway regulates aqueous humor outflow and therefore, intraocular pressure. We investigated the pharmacologic effects of the soluble guanylate cyclase (sGC) stimulator IWP-953 on primary human trabecular meshwork (HTM) cells and conventional outflow facility in mouse eyes. METHODS Cyclic GMP levels were determined in v...

This report describes part of the signaling pathway and some of the molecules involved in the auxin-induced adventitious root formation in cucumber (Cucumis sativus). Previous results showed that nitric oxide (NO) mediates the auxin response during adventitious root formation (Pagnussat et al., 2002). To determine the order of action of indole acetic acid (IAA) and NO within the signal transduc...

The cyclic GMP (cGMP) signaling pathway is a ubiquitous second messenger system that regulates diverse cellular functions. The cGMP-dependent protein kinase G (PKG) is a primary direct cGMP effector in multiple cell types. cGMPPKG signaling plays critical roles throughout the cardiovascular system, although the best understood function of PKG is as an inducer of vascular smooth muscle relaxatio...

Heart disease is the major causes of hospitalization, morbidity and mortality worldwide. Reactive oxygen species (ROS) are proposed to contribute to the deterioration of cardiac function in patients with heart diseases. ROS are increased in the failing heart and involved in atherosclerosis, myocardial ischemia/reperfusion injury, and heart failure. Increased production of ROS directly or indire...