Background: Cyclosporine A (CYA) prevents graft rejection after transplantation, interferon-α (IFN-α ) is a natural cytokine prescribed in some types of malignancies and hepatitis C virus. However neurologic complication such as depression side effect chronic use these drugs. Melatonin apart from its on regulating the circadian rhythm, has potent antioxidant inhibits N-methyl-d-aspartic acid (N...

Abstract Tools to monitor SARS-CoV-2 transmission and immune responses are needed. We present a neutralization ELISA determine the levels of Ab-mediated virus preclinical model focused immunization strategy. The is strongly correlated with elaborate plaque reduction test (? = 0.9231, p < 0.0001). potency convalescent sera correlates IgG titers against receptor-binding domain (RBD) spike ...

Background: Toxoplasma gondii is an important zoonotic pathogen. Vertical transmission of the parasite occurs when females were infected primarily during gestation. This parasite transmitted to the fetus through the placenta and may cause miscarriage, permanent neurological damage, premature birth and visual impairment. Materials and Methods: Two 6-8-week NMRI females mice were crossed with one...

For many years, the presence of yessotoxins (YTXs) in shellfish has contributed to the outcome of the traditional mouse bioassay and has on many occasions caused closure of shellfisheries. Since YTXs do not appear to cause diarrhoea in man and exert low oral toxicity in animal experiments, it has been suggested that they should be removed from regulation. Before doing so, it is important to det...

(1) Background: Ischemia reperfusion (IR) is the leading cause of acute kidney injury (AKI) and results in predisposition to chronic disease. We demonstrated that delayed contralateral nephrectomy (Nx) greatly improved function IR-injured decelerated fibrosis progression. Our aim was identify microRNAs (miRNA/miR) involved this process. (2) Methods: NMRI mice were subjected 30 min renal IR one ...

هدف: ناباروری یک بحران زندگی است که بیماران را در سراسر جهان تحت تاثیر قرار می دهد، به عنوان عدم موفقیت بارداری پس از 12 ماه فعالیت جنسی تعریف شود 15 تا 17 درصد زوج ها تأثیر دهد و حدود 50 آنها عوامل زنان مربوط شود. فعال کردن روند تقسیم میوز اووسیت بلوغ آن اهداف مهم درمانی محققین علوم بوده است. امروزه القا رشد تکامل خارج بدن یکی روش هایی فنّاوری کمکی تولیدمثل کار گرفته مغز استخوان اندام پیچیده ای...

Urine samples of premature babies contain high amounts of thiodiacetic acid (TDA). Since these pre-term infants are exposed to an increased oxygen atmosphere in the incubator, we supposed that these high levels of thiodiacetic acid might be produced from ethylene, generated in the course of lipid peroxidation processes. Considering that conversion of ethylene to ethylene oxide (EO) is well know...