Introduction NMR spectra can be recorded by displaying the intensity of absorption not only as a function of one frequency but also as a function of a second or third variable. This original idea has been suggested by Jeener in 1971 [1] and since then the basic principles and some pioneer experiments of multidimensional NMR spectroscopy have been developed by several groups [2, 3]. In particula...

new biodegradable network polymers containing siloxane-linked polymeric prodrugs of 5-ammino-2-hydroxybenzoic acid (5-asa) in the main chain were prepared by ter polymerization of methacrylic acid (ma), 2-hydroxyethylmethacrylate (hema), and bis (trimethylsilyloxy) methylsilane (vbm) in the presence of some new cross-linking agents.the monomers and polymers were characterized by ft-ir and 1h-nm...

We present a detailed discussion of the complimentary fields of the application of two-dimensional infrared (2D-IR) spectroscopy in comparison with two-dimensional nuclear magnetic resonance (2D-NMR) spectroscopy. Transient 2D-IR (T2D-IR) spectroscopy of nonequilibrium ensembles is probably one of the most promising strengths of 2D-IR spectroscopy, as the possibilities of 2D-NMR spectroscopy ar...

Nuclear magnetic resonance is the most important form of molecular spectroscopy in chemistry and biochemistry but it is normally blind to chirality. It was predicted in 2004 that precessing nuclear spins in chiral molecules in a liquid in a strong magnetic field induce a rotating electric polarization that is of opposite sign for enantiomers. This polarization arises from the distortion of the ...

The process of preclinical drug discovery consists of two steps: finding of initial hits (binding ligands to a medicinal relevant target, usually a protein) and lead optimization. Nuclear magnetic resonance spectroscopy is a powerful tool that can provide valuable information to every step of drug development. NMR is commonly used for characterizing the structure and molecular dynamics of targe...

The recent success of the human genome project and the continued accomplishment in obtaining DNA sequences for a vast array of organisms is providing an unprecedented wealth of information. Nevertheless, an abundance of the proteome contains hypothetical proteins or proteins of unknown function, where high throughput approaches for genome-wide functional annotation (functional genomics) has evo...

We demonstrate the acquisition of double-quantum NMR spectra in less than three seconds and illustrate the synergies between double-quantum and ultrafast NMR spectroscopy for the analysis of complex mixtures.