By means of the ESR spectrum technique it was demonstrated that fluoride (F-) stimulated human polymorphonuclear leukocytes (PMN) in a respiratory burst to generate active oxygen radicals ( • 02 and -OH) and to consume oxygen (02). The experiments' using the spin trapping technique with the nitrone DMPO as the trapping agent indicated that the PMN produce the adduct DMPO-OOH under high concentr...

An approach to β-D-2-aminotalose- and β-D-2-aminoidose-configured carbohydrate mimetics bearing a phenyl substituent is described. Unnatural divalent rigid p-terphenyl-linked C-aryl glycosides with 2.0 nm dimension are available using Suzuki cross-couplings. The key compound, a p-bromophenyl-substituted 1,2-oxazine, was prepared by a stereoselective [3 + 3]-cyclization of a D-isoascorbic acid-d...