Burn injuries are a painful form of trauma.1 Patients of burn injuries experience severe pain on a daily basis, both immediately after the injury and during therapeutic procedures, such as dressing changes,debridement and physiotherapy.2 In addition, repetition of these painful procedures often creates anticipatory anxiety forpatients with burns.3 Anxiety induced by a bad acute pain experience ...

T he transcription of genes by RNA polymerases (RNAPs) is far from a smooth ride. Not only is template sequence-dependent pausing of RNAPs a frequent occurrence (1), lesions within the transcribed strand present major barriers to continuedmovement of RNAPs, with potentially disastrous consequences for gene expression (2). To make matters worse, such stalled transcription complexes mask the DNA ...

Zampieri, Antonio (Palo Alto Medical Research Foundation, Palo Alto, Calif.), and Joseph Greenberg. Effect of heat and plating medium on survival of Escherichia coli after treatment with radiomimetic chemicals. J. Bacteriol. 89:931-936. 1965.-Survival of Escherichia coli strain S and its radioresistant mutant R(4) after treatment with mitomycin C, azaserine, nitrogen mustard, 1-methyl-3-nitro-1...

Many enteric bacteria express a type I oxygen-insensitive nitroreductase, which reduces nitro groups on many different nitroaromatic compounds under aerobic conditions. Enzymatic reduction of nitramines was also documented in enteric bacteria under anaerobic conditions. This study indicates that nitramine reduction in enteric bacteria is carried out by the type I, or oxygen-insensitive nitrored...

For a better understanding of the mechanism of action of the nitrofurans in the mammalian organism, studies of their metabolism have been initiated. Excretion studies (1) have revealed that only a small part of most ingested nitrofurans appears unchanged in the urine. Bender and Paul (2) in preliminary studies have shown that 5-nitro-2-furaldehyde semicarbazone (Furacin’) undergoes degradation ...

The goal of the research work entertained herein was the development and characterization of a poly-(vinyl alcohol) (PVA) hydrogel cross-linked with glutaraldehyde and impregnated with 0.2% (w/w) nitrofurazone (NTZ), for topical applications. To verify the active principle release capability, one has determined (i) swelling profile, (ii) in vitro release of NTZ via UV-VIS spectrophotometry, and...

Nitrofurazone (NF) has been previously demonstrated to induce testicular toxicity with 4 weeks of oral administration in rats, ln the present study, rats were administered NF to assess whether testicular toxicity becomes evident with a 2-week administration period, Male Sprague-Dawley rats were administered oral doses of NF at 50 mgfkg fbr 2 or 4 weeks. Another group was administered NF at 100 ...

In the course of studies of t.he reduction of Furacin (5-nitro-2-furaldehyde semicarbazone) by cell-free extracts of a strain of Escherichia co& the presence of a number of diphosphopyridine nucleotide-linked dehydrogenases was indicated by the ability of such extract’s when dialyzed to reduce the nitrofuran only on the addition of diphosphopyridine nucleotide (DPN) and any one of a number of o...

A L T H O U G H many articles on surgical subjects have been reported in medical journals there have been few articles on the healing of anorectal wounds. For several years at the Medical College of South Caro!ina, a clinical study of postoperative anorectal wound healing has been carried out. In order to obtain objective evidence and to communicate information more accurately, all anorectal wo...