Chronic neuroinflammation and oxidative stress contribute to the neurodegeneration associated with Alzheimer's disease and represent targets for therapy. Ferulic acid is a natural compound that expresses antioxidant and anti-inflammatory activities. Nitric oxide is also a key modulator of inflammatory responses. Grafting a nitric oxide-releasing moiety onto anti-inflammatory drugs results in en...

BACKGROUND The labile nature of live, attenuated varicella-zoster virus (Oka/Merck) requires robust stabilization during virus bulk preparation and vaccine manufacturing in order to preserve potency through storage and administration. One stabilizing ingredient used in a varicella-zoster virus (VZV) vaccine is hydrolyzed porcine gelatin which represents the major protein/peptide-based excipient...

Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN (M.B., F.P.G.); Merck-Serono, RBM S.p.A. Instituto di Ricerche Biomediche A. Marxer, Colleretto Giacosa, TO, Italy (L.B., S.R.); Merck-Serono, Global Early Development, Darmstadt, Germany (H.D.); and Merck-Serono, Global Early Development, Darmstadt/Global DMPK, Grafing, German...

We report theoretical studies on the complexation of uranyl nitrate and the dissolution of nitric acid in supercritical CO2 by TBP. According to quantum mechanical calculations, TBP (modeled by trimethyl phosphate TMP) displays stronger hydrogen-bonding interactions with HNO3 than with H2O, and this has been modeled in force-field calculations. Different combinations of water, TBP, and acid are...

The production and application of compost potentially contaminate the environment with heavy metals. The heavy metal contents of composts must be exactly determined. Therefore, this study aims to understand the heavy metal contents in composts, using different digestion methods and to recommend the most appropriate digestion method making this measurement. Nine composts from different sources, ...

Background and purpose: Determination of heavy metals in oils is necessary to establish quality standards on a country level. This study aimed to determine of heavy metal contents (Cr, Ni, As, Cd, Hg, Pb, Sb, Sn, Sr, Al) in 12 seed oil samples in Iran by inductively coupled plasma-optical emission spectrometry (ICP-OES). Materials and Methods: The concentrations of heavy metal were determined b...

Highly effective refining of precious metals requires detailed knowledge the chemical properties their complexes in leaching solutions. Speciation studies on metal ions solution have been performed for about a century. Early mainly provided stability constants between and ligands. Recently, improvement analytical technologies has facilitated advanced speciation including determination informati...

Preeclampsia is a human pregnancy specific multisystem disease of unknown etiology. It major cause maternal mortality, morbidities, perinatal deaths, preterm birth and intrauterine growth restriction. was aimed to find the role Uric Acid, CRP Nitric Oxide in preeclampsia by comparing their levels with normal pregnant females. As its etiology unknown, so it’s early detection follow up required p...

Lipopolysaccharide-induced nitric oxide and the protease prolyl oligopeptidase (EC 3.4.21.26) have been proposed as targets for the treatment of cognitive disturbances such as dementia. In this study, nine triterpenoids isolated from the roots of Sanguisorba officinalis, including arjunic acid (1), rosamultic acid (2), haptadienic acid (3), 1β-hydroxyeuscaphic acid (4), euscaphic acid (5), torm...