Purpose of present study was to develop eight formulations chlorpheniramine (CPM) niosomes according 23 factorial design, characterise on the basis various evaluation tests, i.e. in vitro drug release, SEM, FTIR, TGA and release kinetics, optimise formulation data, formulate gel optimised dispersion, perform vivo histopathological using dispersion rabbits. Here, N3 having low level cholesterol ...