Sir,?I had a creat mind to send this article, long ago, to be published in your esteemed paper, but ruther shrunk from so doing, as from none of my available books I could find any information with regard to wonderful therapeutic action of White Santonin ordinarily supplied from Government Medical Stores in India. I referred the matter some three months ago to my Medical Officer, Captain J. B. ...

The unhealthy habit of late-night-dinner eating (LNDE) is often observed in adults. Since LNDE can lead to breakfast skipping (BS) the next morning, we examined the associations of LNDE and BS with hyperglycemia (HbA1c ≥ 5.7% and/or pharmacotherapy for diabetes), separately and in combination, in 61,364 apparently healthy Japanese adults aged 30-70 years. Although LNDE alone was significantly a...

Although this assessment of children monitored during the pulse polio rounds does not serve as a formal vitamin A deficiency survey, the number of children assessed and the large number of sites sampled exceeded the minimum numbers of children and clusters required for the most basic vitamin A deficiency survey using night blindness as the main indicator (3,042 children and 30 cluster). The WHO...

Oguchi disease is a rare autosomal recessive form of congenital stationary night blindness. The condition is associated with fundus discolouration and abnormally slow dark adaptation. Earlier studies suggested that the 48 kD protein S antigen may be involved in the recovery phase of light transduction. Previous cytogenetic and linkage studies have localised the S antigen gene (SAG) to chromosom...

Clinical and molecular genetic studies were performed on a single, large, white family, in which congenital nystagmus and moderate to high refractive error segregated as a sex linked trait with manifestation in some female carriers. In this family, affected males demonstrate myopia, but a high proportion of female carriers, and some of the possibly affected males, show hypermetropia. Clinical o...

Phosphorylation is thought to be an essential first step in the prompt deactivation of photoexcited rhodopsin. In vitro, the phosphorylation can be catalyzed either by rhodopsin kinase (RK) or by protein kinase C (PKC). To investigate the specific role of RK, we inactivated both alleles of the RK gene in mice. This eliminated the light-dependent phosphorylation of rhodopsin and caused the singl...