Najjar and Holt (1, 2) have demonstrated that their fluorescent urinary pigments, F1 and F2, are related to nicotinic acid metabolism in such a way that their estimation in urine is of diagnostic use in human pellagra (1) and in canine black tongue (1, 2). As nicotinic acid deficiency progresses, the daily excretion of F1, starting from a low level, slowly rises and then falls again; and the da...

The effects of diabinese, a known antidiabetic drug, and the combined effects of diabinese and nicotinic acid, a vitamin and antilipidemic drug, were studied in rabbits with dithizone-induced diabetes. Side effects of diabinese include hypoglycemia and liver toxicity. Dithizone was used to induce partial experimental diabetes and to increase blood glucose significantly (P < 0.05) by 31.3%, 23.5...

NAD(+) is both a co-enzyme for hydride transfer enzymes and a substrate of sirtuins and other NAD(+) consuming enzymes. NAD(+) biosynthesis is required for two different regimens that extend lifespan in yeast. NAD(+) is synthesized from tryptophan and the three vitamin precursors of NAD(+): nicotinic acid, nicotinamide and nicotinamide riboside. Supplementation of yeast cells with NAD(+) precur...

This work describes a medium-based screening method for selecting microbial biocontrol agents against Erwinia amylovora based on the degradation of a specific growth factor. Erwinia amylovora, the causal agent of the devastating fire blight disease, requires nicotinic acid or nicotinamide as an essential growth factor. Potential biocontrol agents are either selected for antimicrobial production...

On the structural pattern of nikethamide which is a potent central nervous system (CNS) stimulant, it was designed to link N,N-bis(2-chloroethyl)amino moiety as alkylating agent to nicotinic acid by an amide bond in the hope to obtain a CNS antitumor agent (Nicotinic-mustard). The Nicotinic-mustard agent was solid at room temperature and stable for more than one week when stored at less than 0 ...