Abstract Background and Aims Mitochondrial dysfunction in renal cells play a critical role the pathophysiology of acute kidney injury (AKI) chronic disease (CKD). The proximal tubule is primary sensor effector CKD progression AKI. measurement urine Β2-microglobulin (Β2M) sensitive assay for injury. Nicorandil, selective mitochondrial ATP-sensitive potassium channel activator, may be promising A...

ATP-sensitive potassium (KATP) channels are well characterized in cardiac, pancreatic and many other muscle cells. In the present study, functional expression of the KATP channel was examined in non-pregnant murine longitudinal myometrium. Isometric contraction measurements and Western blot were used. KATP channel openers (KCOs), such as pinacidil, cromakalim, diazoxide and nicorandil, inhibite...

Vascular K+ channel openers such as cromakalim, nicorandil, and pinacidil potently stimulate 86Rb+ efflux from slices of substantia nigra. This 86Rb+ efflux is blocked by antidiabetic sulfonylureas, which are known to be potent and specific blockers of ATP-regulated K+ channels in pancreatic beta cells, cardiac cells, and smooth muscle cells. K0.5, the half-maximal effect of the enantiomer (-)-...

BackgroundSpinal cord injury remains a devastating complication of thoracoabdominal aortic surgery. We previously demonstrated that pretreatment with nicorandil preserved motor function in murine spinal model through mitochondrial adenosine triphosphate-sensitive potassium channel activation. hypothesized the neuroprotective effect is mediated by downstream generation reactive oxygen species.Me...

Introduction: Aqueous leave extract of Tridax procumbens (AETPL) is reported to improve erectile functions; however, the mechanism unclear. This study investigates involved in contractile activity corpus cavernosum after AETPL treatment paroxetine-induced dysfunctional adult male Wistar rats.
 Methods: A total 20 rats were categorized into four groups five and treated orally for weeks: Gro...

Bevacizumab, an inhibitor of vascular endothelial growth factor (VEGF)-A, is currently used to treat patients with ovarian or colon cancer. While several cardiovascular toxicities related to bevacizumab-containing regimens have been reported, the effect of bevacizumab on the coronary microcirculation has not been fully elucidated. Here we report a case of 54-year-old female patient who develope...