Background—Several epidemiological studies have demonstrated the beneficial effect of red wine intake in reducing total and cardiovascular mortality. This effect has been attributed in part to its antioxidant properties. Because the monocytes/macrophages and the nuclear transcription factor kB (NF-kB) are implicated in the pathogenesis of atherosclerotic lesions, we examined the effect of red w...

Heptadecane is a volatile component of Spirulina platensis, and blocks the de novo synthesis of fatty acids and ameliorates several oxidative stress-related diseases. In a redox state disrupted by oxidative stress, pro-inflammatory genes are upregulated by the activation of NF-kB via diverse kinases. Thus, the search and characterization of new substances that modulate NF-kB are lively research...

In normal cells exposed to stress, the central transcription factor NF-kB is activated only transiently, to modulate the activation of downstream immune responses. However, in most cancers, NFkB is abnormally activated constitutively, contributing thus to oncogenesis and tumor progression. Therefore, downregulating NF-kBactivity is an important goal of cancer treatment. In order to control NF-k...

Jedrzkiewicz, Sean, Hidetoshi Nakamura, Eric S. Silverman, Andrew D. Luster, Naresh Mansharamani, Kwang Ho In, Gen Tamura, and Craig M. Lilly. IL-1b induces eotaxin gene transcription in A549 airway epithelial cells through NF-kB. Am J Physiol Lung Cell Mol Physiol 279: L1058–L1065, 2000.—Eotaxin is an asthma-related C-C chemokine that is produced in response to interleukin-1b (IL-1b). We detec...

BACKGROUND Various postural deformities appear during progression of Parkinson's disease (PD), but the underlying pathophysiology of these deformities is not well understood. The angle abnormalities seen in individual patients may not be due to distinct causes, but rather they may have occurred in an interrelated manner to maintain a balanced posture. METHODS We measured the neck flexion (NF)...

Our objective was to understand the mechanism through which cells that initially survive irradiation could acquire survival advantage. In this study, we show evidence that low-linear energy transfer c-radiation can induce telomerase enzyme activity in primary aortic endothelial cells, and that an upstream regulator, nuclear factor kappa B (NF-kB), controls this activation. Telomeric repeat ampl...

Han, Bing, and Craig D. Logsdon. CCK stimulates mob-1 expression and NF-kB activation via protein kinase C and intracellular Ca21. Am. J. Physiol. Cell Physiol. 278: C344–C351, 2000.—Supraphysiological concentrations of cholecystokinin (CCK) induce chemokine expression in rat pancreatic acini through the activation of the transcription factor NF-kB. In the current study, the intracellular signa...

Extracellular matrix factors within the tumor microenvironment that control resistance to chemotherapeutics are poorly understood. This study focused on understanding matrix adhesion pathways that control the oral carcinoma response to cisplatin. Our studies revealed that adhesion of HN12 and JHU012 oral carcinomas to carcinoma matrix supported tumor cell proliferation in response to treatment ...

Interleukin-6 (IL-6) is a multifunctional cytokine expressed by angiotensin II (Ang II)-stimulated vascular smooth muscle cells (VSMCs) that functions as an autocrine growth factor. In this study, we analyze the mechanism for Ang II-inducible IL-6 expression in quiescent rat VSMCs. Stimulation with the Ang II agonist Sar Ang II (100 nmol/L) induced transcriptional expression of IL-6 mRNA transc...

The two-feedback-loop regulatory module of nuclear factor kB (NF-kB) signaling pathway is modeled by means of ordinary differential equations. The constructed model involves two-compartment kinetics of the activators IkB (IKK) and NF-kB; the inhibitors A20 and IkBa; and their complexes. In resting cells, the unphosphorylated IkBa binds to NF-kB and sequesters it in an inactive form in the cytop...