Neurofilaments (NFs) are prominent components of large myelinated axons. Previous studies have suggested that NF number as well as the phosphorylation state of the COOH-terminal tail of the heavy neurofilament (NF-H) subunit are major determinants of axonal caliber. We created NF-H knockout mice to assess the contribution of NF-H to the development of axon size as well as its effect on the amou...

Neurofilaments (NFs) are a major constituent of nerve cell axons that assemble from three subunit proteins of low (NF-L), medium (NF-M), and high (NF-H) molecular weight into a 10 nm diameter rod with radiating sidearms to form a bottle-brush-like structure. Here, we reassemble NFs in vitro from varying weight ratios of the subunit proteins, purified from bovine spinal cord, to form homopolymer...

Neurofilaments (NFs) are neuronal intermediate filaments composed of light (NF-L), middle (NF-M), and heavy (NF-H) subunits. NF-L self-assembles into a "core" filament with which NF-M or NF-H co-assembles to form the neuronal intermediate filament. Recent reports show that point mutations of the NF-L gene result in Charcot-Marie-Tooth disease (CMT). However, the most recently described rod doma...

We examine a dual theory of a Supersymmetric Standard Model(SSM) in terms of an SU(3)C gauge group. In this scenario, it is naturally understood that at least one quark (the top quark) should be heavy, i.e., almost the same order as the weak scale. Moreover, the supersymmetric Higgs mass parameter μ can naturally be expected to be small. This model automatically induces nine pairs of composite ...

Neurofilaments (NF), the major cytoskeletal component in neuronal cells, are one of the most highly phosphorylated proteins expressed in brain. Apart from the structural role NFs play in maintaining neuronal architecture, little else is known of their function. We describe here evidence suggesting that NF may support many other proteins in the neuronal axoplasm including protein kinases. In ord...

Objective: The nutrient artery which enters through the foramen (NF) provides blood circulation and nutrition in long bones. This supply is essential during growing period, early phases of ossification, some surgical procedures. study aimed to investigate NF adult human ulnas Turkish population. Methods: For this study, 155 (70 right 85 left) dry were used. presence, number, patency recorded as...

In this review, we supply a framework for the importance of nematophagous fungi (nematophagous [NF]) and their role in agricultural ecosystems. We characterize taxonomy, diversity, ecology, type NF, depending on interaction with plant-parasitic nematodes (PPNs). described potential mechanisms NF control PPNs, efficiency methods utilization, use nematicides sustainable agriculture. explain utili...

The self-compacted concrete (SCC) is a special type of which settles down in the formwork and fills its every corner without any use compaction or vibration. As SCC has higher flow-ability that causes brittle behaviour resulting poor performance under tension bending. inclusion randomly distributed short discrete fibers one most effective way to improve tensile as well flexural SCC. In this reg...

The phosphorylation state of human and bovine spinal cord neurofllaments (NF) was studied by direct phosphate analysis and carbocyanine dye (“Stains-all”) binding to NF polypeptides resolved on SDS-polyacrylamide gels. Electrophoretically purified NF-H (200 kDa), NF-M (160 kDa), and NF-L (66 kDa) of human origin contained 24, 18, and 4 mol phosphatelmol protein, whereas bovine NF contained 53,2...

The synthesis and subsequent modification of neurofilament (NF) polypeptides has been examined in pulse-chase experiments, using cultured chick spinal cord neurons. Fluorography of the [35S]methionine-labeled cytoskeletal proteins, after separation by two-dimensional gel electrophoresis, revealed that (a) the mid-size chicken NF protein, NF-M160, is synthesized as a smaller and more basic precu...