Pilot innovative accelerator based neutron source for neutron capture therapy of cancer [1] is now on the threshold of its operation at the BINP, Russia. One of the main elements of the facility is lithium target producing neutrons via threshold Li(p,n)Be reaction at 25 kW proton beam with energies 1.915 MeV or 2.5 MeV. In the present report, choice of target is substantiated, the main problems...