Aging is the major risk factor for neurodegenerative diseases such as Alzheimer's disease, but little is known about the processes that lead to age-related decline of brain structures and function. Here we use RNA-seq in combination with high resolution histological analyses to show that aging leads to a significant deterioration of neurovascular structures including basement membrane reduction...

The trigeminal neuralgia caused by neurovascular compression is a neurosurgical pathology requiring the preoperative identification as exact as possible of the neurovascular conflict. In this case, neuroimaging is very useful, as it allows not only the determination of the neurovascular conflict of the trigeminal nerve, but also the correct indication of an adequate surgical approach.

BACKGROUND Although percutaneous trigger digit release is common, controversy exists regarding its safety. The purpose of this study was to evaluate the feasibility and safety of the neurovascular displacement by local hydraulic dilatation (LHD) during percutaneous trigger digit release. MATERIAL AND METHODS Ten cadaver hands with 50 digits were dissected in this anatomical study. The distance ...

Objective: Stroke is a kind of disease with high morbidity, high mortality and high disability rate. Since currently available drugs treating cerebral ischemia have many limitations, it is necessary to find a new treatment approaches. The emergence of neurovascular unit provides a new perspective for basic research of stroke. Methods: Summarize the literature of research data relevant on the ne...

PURPOSE To investigate, using MR imaging, neurovascular compression at the ventrolateral medulla oblongata in patients with essential hypertension. METHODS Thirty-two patients with essential hypertension (57.6 +/- 7 years of age), 6 patients with secondary hypertension (56.7 +/- 10.3 years of age), and 18 control subjects (50.5 +/- 11 years of age) were evaluated. Transaxial three-dimensional...

Introduction: The neural regulation of the microcirculation is done by the functional neurovascular unit that is composed of vascular, astroglial and neuronal cells. The neurovascular unit represents the interface between the Central Nervous System and the Vascular System. Objective: This paper reviews the literature on functional neuroimaging with a particular focus on the mechanisms of the ne...

Graves' disease may result in significant proptosis that causes visual loss. This has been traditionally managed surgically by external bony skeleton decompression. Tran nasal endoscopic orbital decompression is as a new technique that avoids the need for cutaneous or gingival incisions. Decompression of the medial orbital wall can be performed up to the anterior wall of the sphenoid sinus. Thi...

We study a multiorbital model for the alkaline iron selenides K(1-x)Fe(2-y)Se(2) using a slave-spin method. With or without ordered vacancies, we identify a metal-to-Mott-insulator transition at the commensurate filling of six 3d electrons per iron ion. For Hund's couplings beyond a threshold value, this occurs via an intermediate orbital-selective Mott phase, in which the 3d xy orbital is Mott...

BACKGROUND This study was designed to compare the efficacy of the transpalpebral versus endoscopic approach to decompression of the supraorbital and supratrochlear nerves in patients with frontal migraine headaches. METHODS The medical charts of 253 patients who underwent surgery for frontal migraine headaches were reviewed. These patients underwent either transpalpebral nerve decompression (...