this paper presents a 54-year-old female with lupus whom severe anaemia due to pure red cell aplasia (prca) was the first manifestation. there was seven years interval between prca onset and diagnosis of lupus. thymectomy due to thymoma had been carried out six years before but anaemia sustained. hypothyroidism and hypoparathyroidism were other associated diseases. severe anaemia and the need f...

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the aberrant production of a broad and heterogenous group of autoantibodies. Even though the presence of autoantibodies in SLE has been known, for more than 60 years, still nowadays a great effort is being made to understand the pathogenetic, diagnostic, and prognostic meaning of such autoantibodies. Antibodies to ds-D...

Growing evidence over the last few years suggests a central role of type I IFN pathway in the pathogenesis of systemic autoimmune disorders. Data from clinical and genetic studies in patients with systemic lupus erythematosus (SLE) and lupus-prone mouse models, indicates that the type I interferon system may play a pivotal role in the pathogenesis of several lupus and associated clinical featur...

References DINES, D.E., CLAGETT, O.T. & GOOD, C.A. (1967) Nontuberculous pulmonary parenchymal conditions predisposing to spontaneous pneumothorax. Journal of Thoracic and Cardiovascular Surgery, 53, 726. DUBOIs, E.L. (1966) Lupus Erythematosus, p. 172. McGrawHill Book Company Inc., New York Blakiston Division. HOFFBRAND, B.l. & BECK, E.R. (1965) 'Unexplained' dyspnoea and shrinking lungs in sy...

INTRODUCTION In systemic lupus erythematosus, acute kidney injury is usually associated with severe lupus nephritis and rarely associated with other glomerular diseases. CASE PRESENTATION We recently encountered a patient with acute kidney injury that was associated with minimal change disease in systemic lupus erythematosus. A 26-year-old Chinese woman who had a history of systemic lupus ery...

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease characterized by multiorgan involvement with diverse clinical presentations. Central nervous system involvement in neuropsychiatric syndromes of SLE (NPSLE), such as cerebrovascular disease and myelopathy, is a major cause of morbidity and mortality in SLE patients. The concomitant occurrence of myelopathy, cerebrovas...

Systemic lupus erythematosus is a multi-system inflammatory disease. The clinical manifestations are diverse. Hepatic manifestation is a rarely seen complication of systemic lupus erythematosus. We report a case of complication of systemic lupus erythematosus presenting as cholestatic hepatitis in a 56-year-old Chinese woman. The cholestatic hepatitis progressed as part of the lupus activity an...

various neurological complications occur in primary or secondary antiphospholipid syndrome (aps) consisting of cerebrovascular attacks, ocular events, dementia, seizure, chorea, and transverse myelopathy that are all related to the titer of antiphospholipid antibodies (apl). we report a patient with chorea and retinal vessel occlusion as manifestations of systemic lupus erythematosus (sle) and ...

systemic lupus erythematosus (sle) is a chronic autoimmune disease which results in damage to various organs. some animal studies have revealed that activation of toll-like receptors (tlrs) is important in the pathogenesis of sle. in the present study, the percentage of different immune cell subsets in 35 sle patients and 38 control subjects was analyzed by flow cytometry. we also assessed the ...