Contraction of the guinea pig saphenous artery induced by stimulation of perivascular nerves consists of an adrenergic and a purinergic component. Neuropeptide Y (NPY) potentiated the neural responses significantly at low stimulation frequencies but not at high frequencies when the contraction was maximal. After blocking the adrenoceptors with phentolamine, significant potentiation of the purin...

Neuropeptide Y (NPY), one of the most abundant peptide transmitters in the mammalian brain, is assumed to play an important role in feeding and body weight regulation. However, there is little genetic evidence that overexpression or knockout of the NPY gene leads to altered body weight regulation. Previously, we developed NPY-overexpressing mice by using the Thy-1 promoter, which restricts NPY ...

Effects of neuropeptide y on single neuronal firing patterns in a genetic rat model of absence epilepsy Date: Effects of neuropeptide y on single neuronal firing patterns in a genetic rat model of absence epilepsy 1 ABSTRACT Absence seizures are most common type of generalized seizures where brain goes into abnormal pathological rhythm characterized by bilateral and synchronous 3Hz spike and wa...

Neuropeptide Y (NPY) is an inhibitory neuromodulator expressed abundantly in the central nervous system that is suspected of being an endogenous antiepileptic agent that can control propagation of limbic seizures. Electrophysiological and pharmacological data suggest that these actions of NPY are mediated by G protein-coupled NPY Y2 and NPY Y5 receptors. To determine whether the NPY Y5 receptor...

The mammalian suprachiasmatic nuclei (SCN) can be synchronized by light, with direct glutamatergic input from the retina. Input to the SCN from the intergeniculate leaflet contains neuropeptide Y (NPY) and can modulate photic responses. NPY can reduce the phase-resetting effect of light or glutamate. We investigated the effect of NPY applied in vitro on light-induced phase shifts of the SCN neu...

The distribution of mRNA encoding neuropeptide Y (NPY) in neurons of the normal human cerebral cortex in surgical biopsy specimens and postmortem brain was studied by in situ hybridization techniques. A 32P-labeled complementary RNA (cRNA) probe was used on cryostat sections of 13 formaldehyde-fixed cortical biopsy specimens. Hybridization to NPY mRNA was found in all samples: after autoradiogr...

Objective: To investigate neuropeptide Y (NPY) on EA E guinea pig Th 1 / Th 2 cell balanced influence, and explore NPY on allergic encephalomyelitis (EAE) morbid role in the immune regulatory mechanisms. Methods: 30 guinea pigs were randomly divided into normal control group, EAE control group, NPY intervention group. Observed three groups guinea pig serum interleukin 4 (IL-4), C interferon (IF...

Neuropeptide Y (NPY) was injected directly into the paraventricular nucleus of the hypothalamus (PVN) of satiated, brain-cannulated rats, and food and water intake were measured 0.5, 1, 2, 4, and 22 hr postinjection. NPY (24, 78, 235, 783, and 2351 pmol/0.3 mul) produced a large, dose-dependent increase in food intake as well as small increase in water intake. The latency to eat was about 10 mi...

Neuropeptide Y (NPY) is widely expressed throughout the nervous system and is known to reduce excitatory (but also inhibitory) synaptic transmission in many CNS areas, leading to the proposal that it is an endogenous antiepileptic agent. In the neocortex, where NPY is present in gamma-aminobutyric acid (GABA)ergic interneurons, its effects on inhibitory and excitatory synaptic activities have n...

Neuropeptide Y and Sympathetic Nervous System in Blood Pressure Regulation To the Editor: We read with great interest the recent article by Dr Michalkiewicz and his colleagues1 dealing with a possible link between neuropeptide Y (NPY) and sympathetic nervous system in the NPY-transgenic rats. The results of their presented study demonstrated that overexpression of endogenous NPY in the transgen...