BACKGROUND To determine the incidence rate and to describe other basic epidemiological data of primary brain tumours in a population-based study in Georgia, performed between March 2009 and March 2011. METHODS Active case ascertainment was used to identify brain tumour cases by searching neuroradiology scan reports and medical records from all participating medical institutions, covering almo...

SUBSPECIALIZATION IN NEUROLOGY: THE ROLE OF THE UNITED COUNCIL FOR NEUROLOGIC SUBSPECIALTIES Lynne P. Taylor, Seattle: I read with interest the debate about general neurology vs subspecialization in neurology and wanted to share my perspective as someone who has recently relocated to a hematologyoncology section at Tufts Cancer Center. For 20 years, I have practiced as both a general neurologis...

To determine the incidence rate and evaluate other basic epidemiologic data of primary brain tumours in Georgia a population-based cohort study was performed between March 2009 and March 2011. Active case ascertainment was used to identify brain tumour cases by searching neuroradiology scan reports and medical records from all participating medical institutions, covering almost 100% of the neur...

OBJECT The number of citations a published article receives is a measure of its impact in the scientific community. This study identifies and characterizes the current 100 top-cited articles in journals specifically dedicated to neurosurgery. METHODS Neurosurgical journals were identified using the Institute for Scientific Information Journal Citation Reports. A search was performed using Ins...

A large number of potential tissue biomarkers has been proposed for brain tumors. However, hardly any have been adopted for routine clinical use, so far. For most candidate biomarkers substantial controversy exists with regard to their usefulness in clinical practice. The multidisciplinary neurooncology taskforce of the Vienna Comprehensive Cancer Center Central Nervous System Unit (CCC-CNS) ad...

UNLABELLED The objective of this study was to compare MRI response assessment with metabolic O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET response evaluation during antiangiogenic treatment in patients with recurrent high-grade glioma (rHGG). METHODS Eleven patients with rHGG were treated biweekly with bevacizumab-irinotecan. MR images and (18)F-FET PET scans were obtained at baseline a...

Abstract BACKGROUND Integrative brain tumour diagnostics indisputably requires comprehensive reporting of molecular markers. The 2021 WHO classification central nervous system (CNS) tumours substantially increased the set markers for routine evaluation, with greater significance to DNA methylation analysis in diagnostics. Limited by investment and batching, smaller labs clinics might suffer maj...

Abstract Background Fluorescence-guided surgery with 5-aminolevulinic acid (5-ALA) is a widely used technique to conduct maximum safe resection of high-grade gliomas (HGG). 5-ALA accumulates in malignant tumor tissue where it metabolized Protoporphyrin IX (PpIX), an agent fluorescence properties. It helps neurosurgeons distinguish between tumor-infiltrated and healthy brain parenchyma. Even tho...