نتایج جستجو برای: neuroendocrine differentiation

تعداد نتایج: 243162  

Journal: :Cancer research 2004
Avedis Kazanjian Deeann Wallis Nicholas Au Rupesh Nigam Koen J T Venken Philip T Cagle Burton F Dickey Hugo J Bellen C Blake Gilks H Leighton Grimes

Human small cell lung cancers might be derived from pulmonary cells with a neuroendocrine phenotype. They are driven to proliferate by autocrine and paracrine neuropeptide growth factor stimulation. The molecular basis of the neuroendocrine phenotype of lung carcinomas is relatively unknown. The Achaete-Scute Homologue-1 (ASH1) transcription factor is critically required for the formation of pu...

2012
Stefano La Rosa Alessandro Marando Fausto Sessa Carlo Capella

The systematic application of immunohistochemical techniques to the study of tumors has led to the recognition that neuroendocrine cells occur rather frequently in exocrine neoplasms of the gut. It is now well known that there is a wide spectrum of combinations of exocrine and neuroendocrine components, ranging from adenomas or carcinomas with interspersed neuroendocrine cells at one extreme to...

2012
G Glück M Mihai R Stoica R Andrei I Sinescu

RATIONALE About 95% of prostate cancers are adenocarcinoamas. Depending on the detection method used, neuroendocrine cells are found in 10% to 100% of prostate cancer specimens. OBJECTIVE A 64-year-old patient was diagnosed in 2006 with adenocarcinoma of the prostate, PSA 4.1 ng/ml, Gleason 6, T3b, positive PSA immunohistochemistry. METHODS AND RESULTS The patient was started on hormone the...

Journal: :Pathobiology : journal of immunopathology, molecular and cellular biology 2009
Eiwa Ishida Mitsutoshi Nakamura Keiji Shimada Masato Tasaki Noboru Konishi

OBJECTIVE To clarify the significance of neuroendocrine differentiation in prostate cancer. METHODS We immunohistochemically examined 96 samples of prostatic cancers obtained from radical prostatectomies using a specific neuroendocrine marker and various neuropeptides, as well as markers for cell proliferation, angiogenesis and androgen-receptor expression. RESULTS We frequently found neuro...

2015
Soner GURSOY Ozan USLUER Ahmet UCVET Serkan YAZGAN Banu YOLDAS Tarik YAGCI

The aim of this study was to evaluate of the results of the treatment of patients who underwent surgery due to large cell lung carcinoma and to analyze the variables affecting the survival outcomes. Pulmonary resections were performed on 1221 patients with pathological stages I, II, III non-small cell lung cancer between January 2003 and January 2013. A total of 85 patients (7%) who were histol...

Journal: :Polish journal of pathology : official journal of the Polish Society of Pathologists 2016
P Czapiewski A Gorczyński J Haybaeck K Okoń J Reszeć W Skrzypczak J Dzierżanowski M Kunc J Karczewska W Biernat

Olfactory neuroblastoma (ONB) is a rare neoplasm of the sinonasal area with neuroendocrine differentiation. ISL-1, TTF-1 and PAX5 are transcription factors that are frequently upregulated in tumors showing neuroendocrine differentiation. The aim of our study was to evaluate these markers in a group of ONBs. We included 11 ONBs from 4 large university hospitals. Immunohistochemical expression of...

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