نتایج جستجو برای: neuroblastoma

تعداد نتایج: 13656  

Journal: :Genetics and molecular research : GMR 2015
Q Gao C F Chen Q Dong L Hou X Chen Y L Zhi X Li H T Lu H Y Zhang

Neuroblastoma is the most common and one of the deadliest among pediatric tumors; however, a subset of infants with neuroblastoma display spontaneous regression. The mechanism of spontaneous regression remains to be elucidated. TrkA plays an essential role in the differentiation and functionality of neurons; abundant TrkA expression is associated with favorable prognosis of neuroblastoma. All-t...

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2013
Susanne Fransson Per Kogner Tommy Martinsson Katarina Ejeskär

BACKGROUND The phosphoinositide 3-kinase (PI3K)/Akt pathway is involved in neuroblastoma development where Akt/PKB activation is associated with poor prognosis. PI3K activity subsequently activates Akt/PKB, and as mutations of PI3K are rare in neuroblastoma and high levels of PI3K subunit p110delta is associated with favorable disease with low p-Akt/PKB, the levels of other PI3K subunits could ...

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2013
Helen M. Ameis Astrid Drenckhan Katharina von Loga Gabriele Escherich Katharina Wenke Jakob R. Izbicki Konrad Reinshagen Stephanie J. Gros

BACKGROUND AND AIM A close relationship between phosphoglycerate kinase 1 (PGK1) and the CXCR4/SDF1 axis (chemokine receptor 4/stromal cell derived factor 1) has been shown for several cancers. However, the role of PGK1 has not been investigated for neuroblastoma, and PGK1 might be a therapeutic target for this tumor entity. The aim of the current study was to evaluate the role of PGK1 expressi...

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Journal: :The Journal of clinical investigation 2018
Liying Chen Gabriela Alexe Neekesh V Dharia Linda Ross Amanda Balboni Iniguez Amy Saur Conway Emily Jue Wang Veronica Veschi Norris Lam Jun Qi W Clay Gustafson Nicole Nasholm Francisca Vazquez Barbara A Weir Glenn S Cowley Levi D Ali Sasha Pantel Guozhi Jiang William F Harrington Yenarae Lee Amy Goodale Rakela Lubonja John M Krill-Burger Robin M Meyers Aviad Tsherniak David E Root James E Bradner Todd R Golub Charles Wm Roberts William C Hahn William A Weiss Carol J Thiele Kimberly Stegmaier

Pharmacologically difficult targets, such as MYC transcription factors, represent a major challenge in cancer therapy. For the childhood cancer neuroblastoma, amplification of the oncogene MYCN is associated with high-risk disease and poor prognosis. Here, we deployed genome-scale CRISPR-Cas9 screening of MYCN-amplified neuroblastoma and found a preferential dependency on genes encoding the pol...

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Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Nan Li Haiying Fu Stephen M Hewitt Dimiter S Dimitrov Mitchell Ho

Neuroblastoma is a childhood cancer that is fatal in almost half of patients despite intense multimodality treatment. This cancer is derived from neuroendocrine tissue located in the sympathetic nervous system. Glypican-2 (GPC2) is a cell surface heparan sulfate proteoglycan that is important for neuronal cell adhesion and neurite outgrowth. In this study, we find that GPC2 protein is highly ex...

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Journal: :Molecular cancer research : MCR 2004
Malin A E Almgren K Cecilia E Henriksson Jennifer Fujimoto Christina L Chang

Nucleoside diphosphate kinase A (NDPK-A), encoded by the nm23-H1 gene, acts as a metastasis suppressor in certain human tumors such as breast carcinoma. However, evidence also points to NDPK-A functioning as a metastasis promoter in other human tumors including neuroblastoma. In fact, amplification and overexpression of nm23-H1 as well as S120G mutation of NDPK-A (NDPK-A(S120G)) have been detec...

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Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2013
Mikhail Burmakin Yao Shi Elisabeth Hedström Per Kogner Galina Selivanova

PURPOSE Restoration of the p53 function in tumors is a promising therapeutic strategy due to the high potential of p53 as tumor suppressor and the fact that established tumors depend on p53 inactivation for their survival. Here, we addressed the question whether small molecule RITA can reactivate p53 in neuroblastoma and suppress the growth of neuroblastoma cells in vitro and in vivo. EXPERIM...

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Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2000
L Prasannan D E Misek R Hinderer J Michon J D Geiger S M Hanash

There is currently substantial interest in the identification of human tumor antigens for diagnosis and immunotherapy of cancer. We have implemented a proteomic approach for the identification of tumor proteins that elicit a humoral response in cancer patients, which we have applied to neuroblastoma. Proteins from neuroblastoma tumors and cell lines were separated by two-dimensional PAGE and tr...

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2008
Tasnim Ara Liping Song Hiroyuki Shimada Nino Keshelava Heidi V. Russell Leonid S. Metelitsa Susan G. Groshen Robert C. Seeger Yves A. DeClerck

Neuroblastoma, the second most common solid tumor in children, frequently metastasizes to the bone marrow and the bone. Neuroblastoma cells present in the bone marrow stimulate the expression of interleukin-6 (IL-6) by bone marrow stromal cells (BMSC) to activate osteoclasts. Here we have examined whether stromal-derived IL-6 also has a paracrine effect on neuroblastoma cells. An analysis of th...

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Journal: :Molecular cancer research : MCR 2012
Jochen Buechner Christer Einvik

Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Amplification and overexpression of the MYCN proto-oncogene occurs in approximately 20% of neuroblastomas and is associated with advanced stage disease, rapid tumor progression, and poor prognosis. MYCN encodes the transcriptional regulator N-myc, which has been shown to both up- and downregulate many target genes involved in...

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