If you are employed in a biomedical laboratory, it is likely that you have worked with HeLa cells. Dependable and hardy, these cells have been used for all manner of scientific research: They’ve been shot into space, exposed to radiation, and treated with cocktails of steroids, hormones, cosmetics, and infectious agents. They were used to develop the polio vaccine, visualize and analyze chromos...

The articles that appear in this issue offer a framework of insights about the neuroanatomy of schizophrenia from three learned and creative perspectives. All three articles advance our understanding of schizophrenia from a single locus/specific "lesion" model to more advanced perspectives of neural circuit dysfunction models. Goldman-Rakic and Selemon review their own and others' work on struc...