Various proteins with different biological activities have been observed to be translocated from the nucleus to the cytoplasm in an energy- and signal-dependent manner in eukaryotic cells. This nuclear export is directed by nuclear export signals (NESs), typically characterized by hydrophobic, primarily leucine, amino acid residues. Moreover, it has been shown that CRM1/exportin 1 is an export ...

The mathematical theory of nonequilibrium steady state (NESS) has a natural application in open biochemical systems which have sustained source(s) and sink(s) in terms of a difference in their chemical potentials. After a brief introduction in Section 1, in Part II of this review, we present the widely studied biochemical enzyme kinetics, the workhorse of biochemical dynamic modeling, in terms ...

Variation in diversification rates is often studied by investigating traits related to species' ecology and life history. Often, however, it is unknown whether these traits evolve gradually or in punctuated bursts during speciation. Using phylogenetic data and species' present-day trait information, we present a novel approach to assessing the mode of character change while accounting for trait...

We present a thorough analysis of nuclear export signals and a prediction server, which we have made publicly available. The machine learning prediction method is a significant improvement over the generally used consensus patterns. Nuclear export signals (NESs) are extremely important regulators of the subcellular location of proteins. This regulation has an impact on transcription and other n...

Ab stract: Ef fec tive ness must be de ter mined for each new tech nol ogy be cause it may have ad van tages and dis ad van tages over what is cur rently of fered. We re viewed the lit er a ture to syn the size in for ma tion on whether telepsychiatry is ef fec tive. Based on the lit er a ture, we sug gest that the ef fec tive ness of telepsychiatry be eval u ated on ac cess to care, qual ity o...

Th is study evaluated changes in shoulder muscle isometric endurance, deltoideus and trapezius muscle electromyographic activity (EMG) and stiff ness in patients with frozen shoulder syndrome (FSS) before and aft er manipulation under general anaesthesia (MUA). Eighteen FSS patients with mean age of 53±9 years participated. Isometric endurance of shoulder muscles was characterized by endurance ...

As a concept, Industry 4.0 encompasses the total transformation of ‘traditional’ production environment with real-time networking products, processes and infrastructure via Internet. What is not clear however, functional relationship between pre-existing operational practices such as Lean Manufacturing 4.0, thus associated organisational qualities ‘Lean-ness’ ‘Smart-ness’ respectively. This wor...

Abstract We investigate how particle pair creation and annihilation, within the quantum transverse XY model, affects non-equilibrium steady state (NESS) Liouvillian gap of stochastic totally asymmetric exclusion process. By utilising operator quantization we formulate a perturbative description NESS. Furthermore, estimate by exploiting Majorana canonical basis as super-operators. In this manner...