Peripheral nerve injury therapy in the clinic remains less than satisfactory. The gold standard of treatment for long peripheral nerve defects is autologous nerve grafts; however, numerous clinical complications are associated with this treatment. As tissue engineering has developed, tissue-engineered nerve grafts (TENGs) have shown potential applications as alternatives to autologous nerve gra...

This article focuses on cell-material interactions of neurons in the context of nerve regeneration and tissue engineering applications. In this review, the cellular and molecular environment of neurons is described in both the uninjured and injured tissue. The interactions between specific materials and neurons is explained, in addition to heterogeneous substrates and guiding scaffolds that are...

Diseases and disorders associated with nervous system such as injuries by trauma and neurodegeneration are shown to be one of the most serious problems in medicine, requiring innovative strategies to trigger and enhance the nerve regeneration. Tissue engineering aims to provide a highly biomimetic environment by using a combination of cells, materials and suitable biological cues, by which the ...

The old wishes of people were to regenerate lost tissues of periodontium that this fact is achieved by gen and cell therapy .Periodontal disease is a chronic inflammation around the tooth by microbes that causes destruction of supporting structure of tissue of tooth such as alveolar bone, cementum and periodontal ligament. For treatment of periodontal diseases we can use the biomaterials which ...

Suitable alternatives are made for damaged or diseased organs and tissues in tissue engineering by combining cellular and molecular biology with materials and mechanical engineering. Fibrin is a critical blood component responsible for homeostasis, used extensively as a biopolymer scaffold in tissue engineering. This study summarizes the latest developments in organ and tissue regeneration usin...

Studies, which evaluated the effects of 632.8nm and 780nm laser irradiation on Schwann 1 and nerve cell 2 cultures and injured peripheral nerves of animals 3-7 showed positive results. Laser phototherapy induces Schwann cell proliferation 1 and affects nerve cell metabolism and induces nerve processes sprouting 2. Laser phototherapy significantly improves recovery of the injured peripheral nerv...

Heart failure is one of the leading causes of death worldwide. End stage disease often requires heart transplantation, which is hampered by donor organ shortage. Tissue engineering represents a promising alternative approach for cardiac repair. For the generation of artificial heart muscle tissue several cell types, scaffold materials and bioreactor designs are under investigation. In this revi...