Nerve sheath tumors are the most common spinal tumors but extradural foraminal nerve sheath tumors are much rarer. Traditionally, these nerve sheath tumors have been resected via an open posterior approach. We describe an alternative minimally invasive (MIS) lateral extracavitary approach for resection of symptomatic extradural foraminal spinal neurofibromas. We describe three consecutive male ...

Schwannomas are peripheral nerve sheath tumors usually detected in adults which extremely rare pediatric population and when present they commonly associated with Neurofibromatosis type 2. While frequently observed the head, neck, extremities, could be anywhere body including abdominal cavity. The most common site for intraabdominal schwannomas is stomach pelvic rare. imaging characteristics qu...

Neurilemmoma is a benign tumour of nerve sheath origin that can arise from myelinated nerve. The Head and neck is the most frequent site involved and other sites are scalp, face, oral cavity, pharynx, larynx, trachea and ear. Neurilemmoma usually occur as solitary lesions and in association with NF type 2. Malignant transformation is very rare. We report a case of 18 year old male presented wit...

Autophagy is an evolutionarily conserved lysosomal degradation pathway that plays an essential role in enabling eukaryotic organisms to adapt to nutrient deprivation and other forms of environmental stress. In metazoan organisms, autophagy is essential for differentiation and normal development; however, whether the autophagy pathway promotes or inhibits tumorigenesis is controversial, and the ...

Peroneal nerve entrapment is most commonly seen in the popliteal fossa. It is rarely caused by a ganglion. Intraneural ganglia, although uncommon and seldom cause serious complications, are well recognized and most commonly affect the common peroneal (lateral popliteal) nerve. Ganglionic cysts developing in the sheath of a peripheral nerve or joint capsule may cause compression neuropathy. The ...

Schwannoma, also known as neurilemmoma, is a slowly growing benign neurogenic tumor, originating from the Schwann cells of nerve sheath. Schwannoma can arise various nerves such cranial nerves, spinal autonomic and most common in head neck area. However, lingual very rare clinical findings are non-specific. Therefore, when it occurs submandibular space, difficult to differentiate them other tum...

Nerve sheath myxomas (NEUROTHEKEOMA) are uncommon tumors of nerve sheet origin. These tumors most frequently arise from in the dermis and subcutaneous tissues of the head and neck, and upper extremities. Neurothekeoma may be either asymptomatic or may present as a painful raised, skin colored, well circumscribed dermal lesion averaging 1 cm in diameter. This entity is especially rare in the foo...

Malignant degeneration of neurogenic tumors has been reported to occur in 1-25% of patients with neurofibromatosis-I, and is the leading cause of cancer-related death in these patients. We report a case of multidisciplinary management of a giant malignant endothoracic nerve sheath tumor leading to histologically proven remission.

By using the D2-40 antibody, we have observed podoplanin expression in Schwann cells and perineurial cells. Podoplanin expression has not been well characterized in peripheral nerve sheath tumors. Because neoplasms of neural crest lineage, including peripheral nerve sheath and melanocytic neoplasms, may share histologic and immunohistochemical characteristics, we evaluated podoplanin and S-100 ...