Specific regulatory pathways in neoplastic cells seem to be responsive to control signals provided by the normal cell/tissue environment. The pres ent experiments were designed to doline, at the molecular level, the growth-regulatory signals in neoplastic cells that are associated with the modulation of expression of the neoplastic phenotype by normal cell populations. When cultured in the pres...

Introduction: Alteration of terminal sugars of Glycoconjugates is one of the important aspects of neoplasia. The aim of the present study was to identify GalNac and GlcNac containing glycoconjugates in different grades of neoplastic cells in adenocarcinoma of colon.  Methods: Histological sections prepared from paraffin blocks belong to 30 patient of colon adenocarcinoma obtained from Khatam...

Accumulating evidence suggests that human cancers develop through a step-wise, but nonlinear process of cellular diversification and evolution. Recent mutational analyses indicate that this process is more complex and diverse than anticipated before whole-genome sequencing methods were readily available. Examples are also emerging now of genetically abnormal clones of cells that have acquired m...

BACKGROUND Rapid on-site evaluation has been proposed as a method to improve the yield of transbronchial needle aspiration. OBJECTIVES This study investigated whether on-site analysis facilitates routine diagnostic bronchoscopy in terms of sampling, yield and cost. METHODS Patients with lesions accessible for transbronchial needle aspiration on computed tomography were investigated. A cytop...

Morphological analysis of transplantable pancreatic acinar carcinoma of rat has revealed a continuum of cells from those which totally lack mature secretory granules to cells with abun dant well-formed secretory granules. This tumor is easily dis sociable into single cells which incorporate [3H]thymidine and [3H]leucine into DNA and protein at a linear rate for 3 to 4 hr. The number of cells sy...