OBJECTIVE To examine whether neonatal seizures are associated with neurodevelopmental outcomes in infants with hypoxia-ischemia independent of the presence and severity of brain injury seen on magnetic resonance imaging (MRI). STUDY DESIGN We used multivariate regression to examine the independent effect of clinical neonatal seizures and their treatment on neurodevelopment in 77 term newborns...

PURPOSE At present, neonatal seizures are usually treated with Phenobarbital (PB) despite the limited efficacy and the potential risk this treatment holds for the developing brain. We report here a prospective pilot feasibility study on the use of Levetiracetam as monotherapy in the treatment of neonatal seizures. METHODS Six newborns (body weight>2000 g, gestational age>30 weeks) presenting ...

OBJECTIVE To estimate whether magnesium therapy is the optimal management for women with mild preeclampsia. METHODS A decision analytic model was designed for women with mild preeclampsia to estimate whether empiric magnesium therapy or no magnesium therapy is the optimal management strategy. The model considered relevant clinical events: seizure, placental abruption, and magnesium toxicity. ...

Abstract Seizures in neonates should prompt rapid evaluation to verify the diagnosis, determine etiology, and initiate appropriate treatment. Neonatal seizure diagnosis requires EEG confirmation clinical observation alone is insufficient. Although most neonatal seizures are related acute brain injury, some present early-onset structural or metabolic/genetic epilepsy. Video-EEG monitoring, gold ...

BACKGROUND Phenobarbitone is the most common first-line anti-seizure drug and is effective in approximately 50% of all neonatal seizures. OBJECTIVE To describe the response of electrographic seizures to the administration of intravenous phenobarbitone in neonates using seizure burden analysis techniques. METHODS Multi-channel conventional EEG, reviewed by experts, was used to determine the ...

objective: although metabolic diseases individually are rare ,but overall have an incidence of 1/2000 and can cause devastating and irreversible effect if not diagnosed early and treated promptly. selective screening is an acceptable method for detection of these multi presentation diseases.method: using panel neonatal screening for detection of metabolic diseases in 650 high risk iranian patie...

This paper describes the design and test results of a 3-stage automated system for neonatal EEG seizure detection. Stage I of the system is the initial detection stage, and identifies overlapping 5-s segments of suspected seizure activity in each EEG channel. In Stage II, the detected segments from Stage I are spatiotemporally clustered to produce multi-channel candidate seizures. In Stage III,...