AIM This study described and compared the perception of hypoglycaemia in both patients with type 1 diabetes and diabetologists. METHODS This was an observational cross-sectional study undertaken in France in 2011. Data for what hypoglycaemia represents and practices related to it were collected using a questionnaire completed by patients with type 1 diabetes (all>12 years of age) and their di...

background & objectives: streptozotocin (stz) is used for induction of type-1 diabetes mellitus in animal models. its beta-cytotoxic action results in sudden release of insulin leading to severe hypoglycaemia and even mortality. however, its sensitivity varies with species. present investigation was aimed at studying stz induced acute clinical effects in rabbits. methods: streptozotocin@ 65...

Two young adults with idiopathic adrenal calcification are described. In one patient the calcification was probably secondary to adrenal haemorrhage in the neonatal period. Neither patient exhibited clinical features suggestive of adrenal cortical insufficiency, and baseline serum cortisol levels were normal. The corticosteroid responses to ACTH administration and to other provocative tests ind...

Continuous glucose monitoring (CGM) is well established in the management of diabetes mellitus, but its role in neonatal glycaemic control is less clear. CGM has provided important insights about neonatal glucose metabolism, and there is increasing interest in its clinical use, particularly in preterm neonates and in those in whom glucose control is difficult. Neonatal glucose instability, incl...

OBJECTIVE To assess the relationship between the timing of antepartum elective caesarean delivery (CD) at term and perinatal outcomes in a Chinese population. METHODS We conducted a retrospective cohort study of mode of delivery at a large obstetric centre in Shanghai, China between 2007 and 2014. Eligibility criteria included: term nulliparous women with a singleton gestation undergoing ante...

BACKGROUND Bilateral optic nerve hypoplasia (BONH) is often associated with other central nervous system midline abnormalities (septo-optic dysplasia). Hormonal dysfunction, caused by anterior (cortisol) and posterior (ADH) pituitary involvement, can be sudden, severe, and life threatening. METHODS Case series. Three cases of septo-optic dysplasia (SOD) presenting as infantile infection with ...

Abstract: Tramadol is most commonly used opioid analgesic. It has a very rare and serious endocrine metabolic side effect as hypoglycaemia. The reason behind hypoglycaemia still unclear but it may lead due to increased insulin concentration utilization of glucose by muscles. In this report, patient prescribed tramadol for toothache. This report focuses on administration. Clinical Pharmacists sh...

Background & Objectives: Alloxan & streptozotocin are used for inducing diabetic models. Their combination has been used to reduce the individual chemical dosage and minimize the side effects. Present investigation was aimed at studying pre-diabetic clinical changes induced by low doses of Alloxan-STZ cocktail in rabbits. Methods: New Zealand White rabbits, 1-1.5 kg body weight, were administe...

We recruited a group of 6713 consecutive Chinese patients with T2D but normal renal and liver function who were admitted to one of 81 top tertiary care hospitals in China. Mild hypoglycaemia was defined as having symptomatic hypoglycaemia in one month before hospitalization. Severe hypoglycaemia was defined as having hypoglycaemia that needed assistance from other people in three months before ...

a 7-year-old castrated male german shepherd dog was presented with a 10-day history of intermittent lethargy, weakness and episodic seizures. laboratory findings after admission revealed hypoglycaemia and hyperinsulinaemia. provisional diagnosis of insulinoma was made based on the presence of concurrent hypoglycaemia and elevated insulin level. in exploratory laparotomy a small nodular mass was...