Many of the effects of prenatal stress on the endocrine function, brain morphology, and behavior in mammals can be reversed by brief sessions of postnatal separation and handling. We have tested the hypothesis that the effects of both the prenatal and postnatal experiences are mediated by negative and positive regulation of neural stem cell (NSC) number during critical stages in neurodevelopmen...

Nearest shrunken centroid classifier (NSC) is a class of linear classifiers with built-in feature selections, and has proven useful for analyzing microarray data. The simple linear structure of the classification boundary makes NSC easy to interpret and implement, but sometimes this simple structure might fail to generalize well for some data. In this paper we propose boosting NSC to improve it...

Abstract At present, the current positive and negative sequence extraction methods are all based on high-performance analog-to-digital converters need microprocessors. Or measurement circuit is constructed using an analog operational amplifier, phase shifting method used to achieve purpose. The above be implemented by chips with high computing power. They even build additional circuit, which ma...

MicroRNAs manifest significant functions in brain neural stem cell (NSC) self-renewal and differentiation through the post-transcriptional regulation of neurogenesis genes. Let-7b is expressed in the mammalian brain and regulates NSC proliferation and differentiation by targeting the nuclear receptor TLX, which is an essential regulator of NSC self-renewal. Whether let-7b and TLX act as importa...

Chemotherapy is a vital therapeutic strategy for castration-resistant prostate cancer (CRPC). We have previously shown that NSC606985 (NSC), a camptothecin (CPT) analog, induced cell apoptosis via interacting with topoisomerase I (Topo I) in prostate cancer cells. In the present study, the effect and mechanism of CPT analogs in LAPC4 cells were investigated. LAPC-4 cells were treated with NSC, ...

Cdc25 dual-specificity phosphatases coordinate cell cycle progression and cellular signaling. Consequently, Cdc25 inhibitors represent potential anticancer agents. We evaluated >10,000 compounds for inhibition of human Cdc25 phosphatases and identified many potent and selective inhibitors, which all contained a quinone. Bioreductive enzymes frequently detoxify or activate quinones. Therefore, w...

We present a high-level parallel calculus for nested sequences, NSC, ooered as a possible theoretical \core" of an entire class of collection-oriented parallel languages. NSC is based on while-loops as opposed to general recursion. A formal, machine independent deenition of the parallel time complexity and the work complexity of programs in NSC is given. Our main results are: (1) We give a tran...

PURPOSE: There is growing evidence that nonsyndromic craniosynostosis (NSC) is associated with functional disabilities in learning and language. To further characterize the neurocognitive changes associated with this condition, we have used auditory event-related potentials (ERPs) to study language acquisition in NSC infants. Mismatch negativity (MMN) is an ERP component that has been used to p...