The optimally re"ned proportional sampling strategy has been recommended as a better alternative to random testing, when dividing the input domain into equal-sized partitions is easy. This paper investigates some properties of the optimally re"ned proportional sampling strategy. This investigation provides some useful information on how well the optimally re"ned proportional sampling strategy o...

Neuroendocrine cells are one of the epithelial populations in the prostate. Neuroendocrine differentiation (NED) has been observed in prostate cancer. In addition to small cell neuroendocrine carcinomas and carcinoid tumors of the prostate, prostatic adenocarcinomas may have NED. The incidence and clinical relevance of NED in prostatic adenocarcinoma is not clearly understood because of conflic...

NED-2 is an intelligent information system for ecosystem management currently in development by the USDA Forest Service. Using PROLOG knowledge bases and inference engines, NED-2 evaluates forest inventories according to a set of predefined goals. It is a blackboard system with agents implemented in PROLOG. NED-2’s primary data store is a set of relational databases. The present paper focuses u...

The pandemic has raised concerns about cancer screening, while also presenting research opportunities.Norman E. “Ned” Sharpless, M.D. Photo credit: NCIOver the past year, COVID-19 affected every facet of oncology care, including prevention efforts. NCI (Bethesda, MD) director Norman Sharpless recently shared his thoughts on and screening diagnosis, outlined key questions that have emerged durin...

Neuroendocrine serum markers released from prostate cancers have been proposed for monitoring disease and predicting survival. However, neuroendocrine differentiation (NED) in various tissue compartments of metastatic prostate cancer is poorly described and its correlation with specific tumor features is unclear. NED was determined by Chromogranin A expression on immunostains from a tissue micr...

Prostate Cancer (PCa)-related deaths are mostly due to metastasization of poorly differentiated adenocarcinomas often endowed with neuroendocrine differentiation (NED) areas.The SNAI2/Slug gene is a major regulator of cell migration and tumor metastasization. We here assessed its biological significance in NED, and metastatic potential of PCa.SNAI2 expression was down-regulated in most PCa epit...

Determining the real-world referents for name mentions of persons, organizations and other named entities in texts has become an important task in many information retrieval scenarios and is referred to as Named Entity Disambiguation (NED). While comprehensive datasets support the development and evaluation of NED approaches for English, there are no public datasets to assess NED systems for ot...

Named Entity Disambiguation (NED) is the task of linking a named-entity mention to an instance in a knowledge-base, typically Wikipedia-derived resources like DBpedia. This task is closely related to word-sense disambiguation (WSD), where the mention of an open-class word is linked to a concept in a knowledge-base, typically WordNet. This paper analyzes the relation between two annotated datase...

This thesis describes the development of a knowledge-based system to evaluate forested land for availability of wildlife habitat. NED is an acronym derived from “Northeast Decision Model”. The NED DSS, a collection of software products, was created to help resource managers to build up goals, access current and potential conditions, and create long-term, landscape-level management plans for for...