Inhaled corticosteroids (ICSs) are the mainstay of anti-inflammatory treatment in subjects with asthma and COPD. This review evaluates the role of nebulizers as an alternative to inhalers for delivering ICSs in asthma and COPD. I selected 16 randomized, placebo-controlled, blinded, long-term studies, mostly carried out in asthma (n = 14) and COPD. Nebulized budesonide has been demonstrated to ...

The two most common albuterol preparations used for nebulization are: (1) Ventolin (albuterol) respirator solution (Glaxo Canada Inc; Montreal, Canada) of which 2.5 mg (0.5 mL) is diluted with 2 mL of normal saline solution, and (2) the preservative-free, prediluted Ventolin (albuterol) Nebules PF (Glaxo) (2.5 mg/2.5 mL). The two preparations were compared using both a Hudson 1720 "T" up-draft ...

Results Six trials (n = 491) met criteria for inclusion. Patients who received b-agonists by MDI+VHC showed a significant decrease in the admission rate compared with those by nebulizer (OR, 0.42; 95% CI, 0.24-0.72; P = .002); this decrease was even more significant among children with moderate to severe exacerbations (OR, 0.27; 95% CI, 0.13-0.54; P = .0003). Finally, measure of severity (eg, c...

Twenty-seven years old Bahraini lady, known to be suffering with fibrosing alveolitis for some eight years, presented to the accident and emergency department of Salmaniya Medical Complex. Recently her respiratory function had deteriorated and she had become house-bound on home oxygen therapy and nebulizers. She was taking Prednisilone tablets and Immuran. She was admitted to the Intensive Care...