The aim of this study was to investigate the effects of the vasodilating -blocker nebivolol and the cardioselective -blocker metoprolol succinate on aortic blood pressure and left ventricular wall thickness. We conducted a randomized, double-blind study on 80 hypertensive patients. The patients received either 5 mg of nebivolol or 50 to 100 mg of metoprolol succinate daily for 1 year. Their hea...

The present investigation aimed to prepare a self micro emulsifying drug delivery system (SMEDDS) for the dissolution enhancement of nebivolol hydrochloride. main objective this work was develop, characterize, and evaluate solid SMEDDS prepared by using adsorption technique liquid improve solubility rate excipients were chosen based on high hydrochloride, their concentrations optimized construc...

BACKGROUND We hypothesized that the combination of nebivolol and lifestyle modification would reduce large artery stiffness in middle-aged and older hypertensive adults more than either intervention alone. METHODS To address this, 45 men and women (age 40-75 years) with stage I hypertension were randomized to receive either nebivolol (NB; forced titration to 10 mg OD; n = 15; age 57.2 ± 11.4 ...

Nebivolol hydrochloride is a poorly water soluble drug falls under class II biopharmaceutical classification system, which is β1 receptor antagonist that leads to vasodilatation, decreased peripheral vascular resistance, lowers blood pressure and heart rate. The rate of its oral absorption is often controlled by dissolution rate in the gastro intestinal tract. The aim of the present investigati...

Angiotensin II contributes to myocardial tissue remodeling and interstitial fibrosis through NADPH oxidase-mediated generation of oxidative stress in the progression of heart failure. Recent data have suggested that nebivolol, a third-generation β-blocker, improves diastolic dysfunction by targeting nitric oxide (NO) and metabolic pathways that decrease interstitial fibrosis. We sought to deter...

BACKGROUND The significance of beta-blockers in the treatment of cardiovascular diseases is well established. The effect of vasodilating beta-blockers on endothelial function and prothrombotic state has not been investigated. METHODS The study comprised 550 consecutive patients with uncomplicated essential hypertension. They were treated with celiprolol, carvedilol or nebivolol monotherapy (1...

BACKGROUND We aimed to assess the effects of irbesartan and nebivolol on the left atrium (LA) volume and deformation in the patients with mild-moderate hypertension. PATIENTS AND METHODS The study comprised of 160 patients (mean age: 55.6±9.6 years), who had Stage 1 or 2 hypertension according to the European Society of Cardiology (ESC) and have not been receiving antihypertensive therapy. Th...

Beta blockers play an important role in the treatment of many cardiovascular diseases. Despite their beneficial effect, the significant difference in their pharmacological properties will influence their metabolic effect. The aim of the present study is to compare the metabolic effect of 4 different beta blockers; two nonvasodilator beta blockers (a non-selective beta blocker, propanolol and ca...