نتایج جستجو برای: ndm

تعداد نتایج: 1520  

Journal: :Journal of clinical microbiology 2012
Adrian J Brink Jennifer Coetzee Cornelis G Clay Sindi Sithole Guy A Richards Laurent Poirel Patrice Nordmann

This report documents emergence of New Delhi metallo-beta-lactamase (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC-2) in K. pneumoniae and Enterobacter cloacae in South Africa. NDM-1 producers have not been described in South Africa, and this is the first instance that KPC producers have been identified in Africa. The two patients infected with these carbapenemase-producing bacteria demised.

Journal: :Journal of Archives in Military Medicine 2022

Background: Pseudomonas aeruginosa is an important opportunistic pathogen, and carbapenem resistance emerging problem. The determination of genes vital for epidemiological purposes, the early carbapenemase production methods also recommended. Objectives: present study aimed to investigate presence VIM, NDM, IMP, GES, SPM, GIM, SIM in P. isolates. Methods: In this study, 200 carbapenem-resistant...

2011
Yared Tekabe Xiaoping Shen Joane Luma Drew Weisenberger Shi Fang Yan Roland Haubner Ann Marie Schmidt Lynne Johnson

BACKGROUND Receptor for advanced glycation endproducts (RAGE) expression contributes to the impaired angiogenic response to limb ischemia in diabetes. The aim of this study was to detect the effect of increased expression of RAGE on the angiogenic response to limb ischemia in diabetes by targeting αvβ3 integrin with 99mTc-labeled Arg-Gly-Asp (RGD). METHODS Male wild-type (WT) C57BL/6 mice wer...

2015
Ji Youn Sung Sun Hoe Koo Semi Kim Gye Cheol Kwon

Carbapenemase production has been reported worldwide in gram-negative bacteria, including Acinetobacter species. We detected carbapenemase-producing Acinetobacter pittii in clinical isolates in Daejeon, Korea. Twenty-one ertapenem-resistant A. pittii isolates screened with a disk diffusion method were characterized by using the Epsilon test, four multiplex PCR assays, and a multilocus sequence ...

2016
Hao Yang Mahesh Aitha Amy R. Marts Alyssa Hetrick Brian Bennett Michael W. Crowder David L. Tierney

In an effort to characterize the roles of each metal ion in metalloβ-lactamase NDM-1, heterodimetallic analogues (CoCo-, ZnCo-, and CoCd-) of the enzyme were generated and characterized. UV−vis, H NMR, EPR, and EXAFS spectroscopies were used to confirm the fidelity of the metal substitutions, including the presence of a homogeneous, heterodimetallic cluster, with a single-atom bridge. This mark...

Journal: :Journal of clinical microbiology 2011
Marco Maria D'Andrea Claudia Venturelli Tommaso Giani Fabio Arena Viola Conte Paola Bresciani Fabio Rumpianesi Annalisa Pantosti Franco Narni Gian Maria Rossolini

We report on the first detection of the NDM-1 carbapenemase in Italy, in Escherichia coli isolated in October 2009. Prolonged colonization and relapsing infection by NDM-1-positive E. coli were observed in a patient (index case) with an indirect epidemiological link with areas of endemicity. Transient colonization was apparently observed in another patient linked with the index case.

2013
Yang Sun Yang Song Hongbin Song Jun Liu Pengzhi Wang Shaofu Qiu Shuo Chen Lingwei Zhu Xue Ji Zhongqiang Wang Nan Liu Liliang Xia Weijun Chen Shuzhang Feng

The NDM-1 gene is a significant public health concern. Acinetobacter is one of the most prevalent opportunistic pathogens causing recent nosocomial infections with NDM-1, and drug-resistant strains pose serious threats to public health worldwide. Herein, we present the genomic sequence of Acinetobacter calcoaceticus subsp. anitratus XM1570, a multidrug-resistant isolate that carries the blaNDM-...

2013
Yu-Chieh Liao Ying-Hsiang Chen Hsin-Hung Lin Jung-Jung Mu Ho-Sheng Wu Feng-Chi Chen Chao Agnes Hsiung

Multidrug-resistant New Delhi metallo-β-lactamase 1 (NDM-1)-producing bacteria have spread globally and become a major clinical and public health threat. We report here the draft genome sequence of the Klebsiella pneumoniae clinical isolate 303K, harboring an NDM-1 coding sequence.

Journal: :Journal of periodontal research 2016
D A Tipton A A Hatten J P Babu M Kh Dabbous

BACKGROUND AND OBJECTIVE Gingival fibroblasts have the potential to participate in periodontal inflammation and breakdown, producing interleukin (IL)-6 and matrix metalloproteinase (MMP)-3. Advanced glycation end products (AGEs), formed during diabetic hyperglycemia, might aggravate periodontal inflammation. The cranberry contains anti-inflammatory polyphenols, which inhibit proinflammatory act...

Journal: :JAMA 2014
Lauren Epstein Jennifer C Hunter M Allison Arwady Victoria Tsai Linda Stein Marguerite Gribogiannis Mabel Frias Alice Y Guh Alison S Laufer Stephanie Black Massimo Pacilli Heather Moulton-Meissner J Kamile Rasheed Johannetsy J Avillan Brandon Kitchel Brandi M Limbago Duncan MacCannell David Lonsway Judith Noble-Wang Judith Conway Craig Conover Michael Vernon Alexander J Kallen

IMPORTANCE Carbapenem-resistant Enterobacteriaceae (CRE) producing the New Delhi metallo-β-lactamase (NDM) are rare in the United States, but have the potential to add to the increasing CRE burden. Previous NDM-producing CRE clusters have been attributed to person-to-person transmission in health care facilities. OBJECTIVE To identify a source for, and interrupt transmission of, NDM-producing...

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