OBJECTIVE To quantify patterns of Natural Health Product (NHP) use in Canada. METHODS The Food Habits of Canadians surveyed 1,543 Canadian adults using a 24-hour recall to record dietary supplements. Prevalence of use by user profile was examined. RESULTS Forty-six percent of women and 33% of men reported taking at least one Natural Health Product with a mean of 2.3 among users. The highest...

An important aim in biology research is the elucidation of the role of proteins in complex, dynamic biological systems through the selective perturbation of their function. In contrast to genetic perturbations, chemical perturbations of protein function are conditional, acute, easily tuneable and reversible. [1] Furthermore, drug development still largely depends on the availability of bioactiv...

www.JCE.DivCHED.org • Vol. 81 No. 8 August 2004 • Journal of Chemical Education 1131 Chocolate, a natural product, is as much a part of our daily lives as television or cell phones. Nevertheless, most of us are completely unaware of the complex chemistry and technology involved in the production of a simple chocolate bar. Beginning chemistry students are rarely exposed to natural products and c...

This review discusses successful strategies and potential pitfalls to assembling a natural product-based library suitable for high-throughput screening. Specific extraction methods for plants, microorganisms, and marine invertebrates are detailed, along with methods for generating a fractionated sub-library. The best methods to store, maintain and prepare the library for screening are addressed...

The fields of natural product total synthesis and combinatorial chemistry have major differences as well as much in common. Unique to combinatorial chemistry is the need to devise rapid and efficient methods for parallel synthesis and purification, while an area of overlap is the targeting of natural product scaffolds for combinatorial libraries. Both these aspects are illustrated with examples...

Diabetes is a chronic disease that affects over 400 million people globally. With 5.5% increase in diabetes related deaths in 2010, as compared to the 2007 and World Health Organisation's projection of diabetes as the 7 th leading cause of death by 2030, has dazed the current drug discovery fraternity. The major focus of drug discovery has been towards the control of hyperglycemia while the sev...

Natural products (NPs) have historically been a fertile source of new drugs for the pharmaceutical industry. However, this once-popular approach has waned considerably over the past two decades as the high-throughput screening of megalibraries comprised mainly of molecules with non-natural (synthetic) motifs has unfolded. Contemporary high-throughput screening libraries contain molecules compli...

Natural products remain an important source of drug candidates, but the difficulties inherent to traditional isolation, coupled with unacceptably high rates of compound rediscovery, limit the pace of natural product detection. Here we describe a reactivity-based screening method to rapidly identify exported bacterial metabolites that contain dehydrated amino acids (i.e., carbonyl- or imine-acti...

Ole Andreas Andersen received hisM.Sc and Ph.D from theUniversity of Tromsø, Norway, in 1998 and 2003, respectively. His Ph.Dwork was supervised by Prof. Edward Hough and comprised crystallographic and biochemical studies on human phenylalanine hydroxylase. Andersen had a postdoctoral fellowship for one year at The Norwegian Structural Biology Centre in Tromsø under the supervision of Prof. Arn...