perform regioand stereo-selective reactions on organic compounds. The different possible microbial reactions include oxidation, reduction, and degradative reactions. Many of these reactions allow the production of new compounds that would be extremely difficult to synthesize chemically. For instance hydroxylation at inactivated methylene is a very common microbial reaction. The results obtained...

Cancer is defined as a multifactorial disease because it exhibits the continuous proliferation of malignant cells. It one principal causes death worldwide, with breast cancer occurrence being highest among women and lung men. Hydroxyflavanones come under category flavonones are further classified 2′-hydroxyflavanone, 4′-hydroxyflavanone, 6-hydroxyflavanone, 7-hydroxyflavanone, etc. Flavonoids c...

The secondary metabolome of an undescribed stereaceous basidiomycete (BY1) was investigated for bioactive compounds. Along with a known fomannoxin derivative and two known vibralactones, we here describe three new compounds of these natural product families, whose structures were elucidated using 1D and 2D NMR spectroscopy and high-resolution mass spectrometry. The new compound vibralactone S (...

Corresponding author: Ryszard ŁAŹNY Ph.D., D.Sc., Professor, e-mail: [email protected] Introduction Stereochemical elucidation of bioactive natural products is of paramount importance for understanding their chemical and biological properties. Tropane alkaloids are a well-known and important class of natural products because of their pharmacological activities as anticholinergic agents. They are...