Antioxidants are a class of molecules that provide a protective function against reactive oxygen species (ROS) in biological systems by out competing physiologically important molecules for ROS oxidation. In natural waters, the reactivity of antioxidants gives an estimate of oxidative stress, and may determine the reactivity and distribution of reactive oxidants. We present an analytical method...

In this study we investigated the effects of Caesalpinia decapetala (CD) extracts on lipid oxidation in ground beef patties. Plant extracts and butylated hydroxytoluene (BHT) were individually added to patties at both 0.1% and 0.5% (w/w) concentrations. We assessed the antioxidant efficacy of CD by the ferric reducing antioxidant power (FRAP) assay and evaluated their potential as natural antio...

Radical-scavenging antioxidants play crucial roles in the protection of unsaturated oils against autoxidation and, especially, edible oils rich in omega-3 because of their high sensitivity to oxygen. Two complementary tools are employed to select, among a large set of natural and synthetic phenols, the most promising antioxidants. On the one hand, density functional theory (DFT) calculations pr...

Natural myo-inositol phosphate antioxidants containing the 1,2,3-trisphosphate motif bind Fe(3+) in the unstable penta-axial conformation.

Antiaging skin care represents a large segment of the cosmetic products market. Such products typically claim to contain the ultimate “miracle in a jar,” that is, a unique active molecule that maintains the youthful aspect of the skin by promoting cellular activity in the epidermis and the dermis. To the best of our knowledge, however, there is no such miracle antiaging compound: the best curre...

The balance between free radicals and antioxidants is an important factor for maintaining health and slowing disease progression. The use of antioxidants, particularly natural antioxidants, has become an important strategy for dealing with this cause of widespread diseases. Natural antioxidants have been used as therapeutic tools against many diseases because they are safe, effective, and inexp...

The incidence and mortality of heart disease are the highest among all diseases all over the world, and are still increasing with a world wide rise in living standards. To find effective treatments for prevention and curing heart disease, it is important to understand the mechanisms behind the cause and the development of the disease. Increasing evidences have shown that reactive oxygen species...

Nephrotoxicity is the major limitation for the clinical use of cisplatin as an anti-tumoural drug. Intracellular effects of cisplatin cause tubular damage and tubular dysfunction with sodium, potassium, and magnesium wasting. Renoperotective strategies against cisplatin are classified on 8 targets: 1) Decrease of cisplatin uptake by renal cell, 2) Inhibition of cisplatin metabolism, 3) Blocking...

Pytochemicals of food and herbs are very potent antioxidants and free radical scavengers. It is accepted that these chemicals minimize DNA damage by reacting with free radicals and in this way they could prevent cancer. However, in some studies antioxidants increase incident of cancers instead of lowering it. These trials have caused a rethinking of the use of natural compounds as chemopreventi...