نتایج جستجو برای: nasal vaccine
تعداد نتایج: 152195 فیلتر نتایج به سال:
BACKGROUND Classical swine fever (CSF) or hog cholera is a highly contagious swine viral disease. CSF endemic countries have to use routine vaccination with modified live virus (MLV) vaccines to prevent and control CSF. However, it is impossible to serologically differentiate MLV vaccinated pigs from those infected with CSF virus (CSFV). The aim of this study is to develop a one-dose E2-subunit...
هدف: این مطالعه به منظور بررسی نتایج nasal tip augmentation با استفاده از غضروف اتوژن در مراجعین به مراکز جراحی تخصصی شهر تهران و بیمارستان بوعلی طی سال های 88-89 انجام شده است. روش مطالعه: 36 فرد تحت nasal tip augmentation با استفاده از غضروف اتوژن در این مطالعه مورد بررسی قرار گرفتند که نتایج به دست آمده و میزان رضایتمندی در بیماران مشخص گردید و ارتباط فاکتورهای دموگرافیک با آن ارزیابی شد. ...
Cholera toxin (CT) is frequently used as an experimental adjuvant intranasally for the induction of systemic and mucosal immunity. However, CT is highly reactogenic and not approved for use in humans. To define the cytokine requirements for the nasal activation of the systemic and mucosal immune system, and to design new adjuvants with efficacy similar to CT, we defined the cytokines that were ...
We made an H1N1 vaccine candidate from a virus library consisting of 144 ( = 16 HA×9 NA) non-pathogenic influenza A viruses and examined its protective effects against a pandemic (2009) H1N1 strain using immunologically naïve cynomolgus macaques to exclude preexisting immunity and to employ a preclinical study since preexisting immunity in humans previously vaccinated or infected with influenza...
BACKGROUND Since the end of 2011 an outbreak of pseudorabies affected Chinese pig herds that had been vaccinated with the commercial vaccine made of Bartha K61 strain. It is now clear that the outbreak was caused by an emergent PRV variant. Even though vaccines made of PRV Bartha K61 strain can confer certain cross protection against PRV variants based on experimental data, less than optimal cl...
Anthrax remains a serious threat worldwide as a bioterror agent. A second-generation anthrax vaccine currently under clinical evaluation consists of a recombinant Protective Antigen (rPA) of Bacillus anthracis. We have previously demonstrated that complete protection against inhalational anthrax can be achieved in a rabbit model, by intranasal delivery of a powder rPA formulation. Here we descr...
This brief review will focus on nasopharynx-associated lymphoid tissue as a unique inductive immune site for B cell responses and plasma cell generation. The anatomical and immunological characteristics of Waldeyer's lymphoid ring should make the nasal route for vaccine administration highly relevant in future clinical trials to stimulate both mucosal and systemic immunity. In this context, the...
Whereas most of the background information and policy statements remain the same in the two position papers, the 2005 paper emphasises developments during the period 2002-2005 especially in the fields of: 1. vaccination of children 2. live, attenuated influenza vaccines for nasal application 3. the epidemiology of influenza in developing countries 4. utilization of influenza vaccines among the ...
Historically, vaccine safety assessments have been conducted by animal testing (e.g., quality control tests and adjuvant development). However, classical evaluation methods do not provide sufficient information to make treatment decisions. We previously identified biomarker genes as novel safety markers. Here, we developed a practical safety assessment system used to evaluate the intramuscular,...
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