Background Intranasal sprays must be delivered to the nasal cavity in sufficient volume, appropriate viscosity and droplet size and with a technique that allows optimal retention, maximizes absorption from the mucosa, and the potential for maximum therapeutic effect. The aim of this study was to evaluate nasal drug run-off after administration of MP29-02* (a novel intranasal formulation of azel...

The cyclodextrins have a wide range of applications in different areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. The most common pharmaceutical application of cyclodextrin is to enhance the solubility, stability, safety and bioavailability of drug molecules. The purpose of this review is to discuss and summarize some of t...

Thermoreversible biogels can serve as effective systems for delivery of drugs through nose with increased nasal residence time. The objective of this study was to use chitosan and glycerophosphate based thermoreversible systems for delivery of doxepin to brain through intranasal administration. Formulations were prepared by admixture of suitable dilutions of chitosan and glycerophosphate with o...

Introduction: Lobular capillary hemangioma (LCH) is a benign lesion of vascular origin. It rarely involves nasal cavity which most commonly manifests as progressive nasal obstruction and epistaxis. Case Report: In this report we present a case of LCH of the nasal cavity which occurred approximately one month after delivery. There was no recurrence after complete endoscopic resection during ...

Drug administration via high flow nasal cannula (HFNC) has been described in pediatrics but the amount of albuterol delivery with an HFNC is not known. The purpose of this study is to quantify aerosol delivery with heliox and oxygen (O(2)) in a model of pediatric ventilation. A vibrating mesh nebulizer (Aeroneb Solo, Aerogen) was placed on the inspiratory inlet of a heated humidifier and heated...

introduction: spontaneous perforation of the nasal septum is an uncommon condition. nasal inhalation of substances such as cocaine has long been linked to this perforation. case report: this report describes the case of a 46-year-old woman who was addicted to methamphetamine and who presented with perforation of the nasal septum.this is the first reported case of nasal septal necrosis linked to...

The rationale of this study acquaint with improvement of sertraline hydrochloride (STH) solubility, formulation of STH nanoemulsion (NE) for intranasal delivery to achieve rapid onset of action and to omit first pass effect with enhanced bioavailability. STH nanoemulsion (NE) system was formulated consisting of capmul MCM as oil phase, tween 80 as surfactant and propylene glycol as cosurfactant...

introduction: lobular capillary hemangioma (lch) is a benign lesion of vascular origin. it rarely involves nasal cavity which most commonly manifests as progressive nasal obstruction and epistaxis. case report: in this report we present a case of lch of the nasal cavity which occurred approximately one month after delivery. there was no recurrence after complete endoscopic resection during one ...

The adequate amount of drug delivery to the brain in neurological patients is a major problem faced by the physicians. Recent studies suggested that intranasal administration of liposomal formulation may improve the drug delivery to the brain. In the present study, an attempt was made to study the brain bioavailability of commonly used anti-Alzheimer drug donepezil (DNP) liposomal formulation b...

Bidirectional nasal drug delivery is a new administration principle with improved deposition pattern that may increase nasal drug uptake. Twelve healthy subjects were included in this open, non-randomized 3-way crossover study: midazolam (3.4 mg) intravenously (1 mg mL (-1)), or nasally by bidirectional or traditional spray (2 x100 microL of a 17 mg mL(-1) nasal midazolam formulation). The prim...