background: nasal continuous positive airway pressure (ncpap) is an effective method of ventilation in newborns with respiratory distress syndrome (rds). using an appropriate nasal skin care protocol is identical to prevention or reduction of nasal skin breakdown in those who receive ncpap. this study aimed to investigate the effectiveness of an evidence-based clinical care protocol on nasal sk...

Background: Chronic or recurrent rhinosinusitis (CRS) is a disease associated with impaired quality of life and substantial societal costs. Many cases present without a clear underlying cause and despite the lack of etiology current treatment protocols dictate intervention with antibiotics, anti-inflammatory drugs or surgery often with poor long-term outcome. Recent studies indicate that commen...

The use of nasal cavity as a route of administration of drugs, specifically systemically acting drugs that pose a delivery challenge, have become an area of great interest to the pharmaceutical companies in the past decade. The physiology of the nasal cavity allows for variety of drug delivery possibilities and destinations which include local, systemic, vaccine, and access to the central nervo...

The purpose of this study was to compare the pharmacokinetic profiles of tetramethylpyrazine phosphate (TMPP) in plasma and extracellular fluid of the cerebral cortex of rats via three delivery routes: intranasal (i.n.), intragastric (i.g.) and intravenous (i.v.) administration. After i.n., i.g. and i.v. administration of a single-dose at 10 mg/kg, cerebral cortex dialysates and plasma samples ...

STUDY OBJECTIVES To determine the optimal method of delivering supplemental oxygen during flexible bronchoscopy (FB). DESIGN Prospective study. SETTING University medical center. PATIENTS Ninety-seven consecutive patients undergoing outpatient nasal FB during a 7-month period. INTERVENTION During FB, delivery of oxygen was alternated weekly and administered by nasal cannula either nasal...

Nasal congestion is one of the most troublesome symptoms of many upper airways diseases. We characterized the effect of selective α2c-adrenergic agonists in animal models of nasal congestion. In porcine mucosa tissue, compound A and compound B contracted nasal veins with only modest effects on arteries. In in vivo experiments, we examined the nasal decongestant dose-response characteristics, ph...

Nasal congestion is one of the most troublesome symptoms of many upper airways diseases. We characterized the effect of selective a2c-adrenergic agonists in animal models of nasal congestion. In porcine mucosa tissue, compound A and compound B contracted nasal veins with only modest effects on arteries. In in vivo experiments, we examined the nasal decongestant dose-response characteristics, ph...

researchers within the last few decades because of its great potential utility for rapid drug delivery. It offers an attractive alternative for drugs that have limited oral bioavailability, are destroyed by gastrointestinal (GI) fluid, or are highly susceptible to hepatic first pass or gut-wall metabolism. Nasal drug delivery also offers the convenience and safety of noninvasiveness. In additio...