In vitro antiviral activities of three flavonoids; fisetin, naringenin and rutin against DENV-2 (NGC strain) were evaluated. Inhibitory effects of each compound at the different stages of DENV-2 infection were examined using foci forming unit reduction assay (FFURA) and quantitative real-time polymerase chain amplification (qRT-PCR). Fisetin, rutin and naringenin showed cytotoxic effects agains...

Flavonoids, polyphenolic compounds that exist widely in plants, inhibit cell proliferation and increase cell differentiation in many cancerous and noncancerous cell lines. Because terminal differentiation of preadipocytes to adipocytes depends on proliferation of both pre- and postconfluent preadipocytes, we predicted that flavonoids would inhibit adipogenesis in the 3T3-L1 preadipocyte cell li...

It was hypothesized that 5,7,4'-OH-flavonoids disappeared more rapidly from human fecal incubations and were less absorbable by humans than flavonoids without 5-OH moieties. Anaerobic fecal disappearance rates over 24 h were determined for 15 flavonoids in samples from 20 men and 13 women. In these anaerobic fecal mixtures, flavonoids with 5,7,4'-OH groups, genistein, apigenin, naringenin, lute...

results the results reveal that pq can decrease mitochondrial viability, deplete gsh content, increase mitochondrial ros formation, and enhance lpo and mitochondrial membrane damage. the pretreatment of mitochondria with ng has the ability to reduce the toxic effects of pq in isolated mitochondria. background paraquat (pq) is a dipyridyl herbicide that sustains damage due to redox cycling. an i...

Mol. Nutr. Food Res. 2021, 65, 202100268 DOI: 10.1002/mnfr.202100268 In article number 2100268, Martha A. Belury and co-workers found that dietary supplementation of naringenin improves multiple aspects metabolic disturbance during cancer cachexia progression in the C-26 mouse model. The cover image by graphic designer Pamela Galante is a pattern depicting food sources naringenin, interplay bet...

Naringenin, widely distributed in fruits and vegetables, is endowed with antiviral other health beneficial activities, such as immune-stimulating anti-inflammatory actions that could play a role contributing, to some extent, either preventing or alleviating coronavirus infection. Several computational studies have identified naringenin one of the prominent flavonoids can possibly inhibit intern...

Abstract Background This study set out to look at how naringenin affected the pharmacokinetics of ranolazine in rats. The pharmacokinetic investigation rats following oral administration with or without coadministration was successfully conducted using established technique. Animals were administered same medications for 7 days as part a multiple dosage (MDS), and amount plasma calculated on 18...

BACKGROUND Natural products have numerous medicinal applications and play important roles in the biology of the organisms that accumulate them. Few methods are currently available for identifying proteins that bind to small molecules, therefore the discovery of cellular targets for natural products with pharmacological activity continues to pose a significant challenge in drug validation. Simil...

The development of efficient microbial processes for the production of flavonoids has been a metabolic engineering goal for the past several years, primarily due to the purported health-promoting effects of these compounds. Although significant strides have been made recently in improving strain titers and yields, current fermentation strategies suffer from two major drawbacks-(1) the requireme...