The different pharmacological syndromes produced by morphine and related drugs in the chronic spinal dog led Martin and his colleagues (1,2) to suggest that these drugs exert their agonist actions 0y interacting with three distinct receptors (~,K, and e). Morphine was hypothesized to be an agonist for the p receptor, ketazocine (ketocyclazocine) was an agonist for the K receptor, and SKF-10,0q7...

Since its inception in 1968, the San Francisco Drug Treatment Program, Inc., has responded to the mental and physical health needs of narcotic addicts. The search for safer, cost-effective detoxification alternatives grew from the controversial use of methadone and propoxyphene napsylate (Darvon N R) and has led to an exploration of nontraditional methods of detoxification which would address t...

S. HERLING, R.J. VALENTINO, R.E. SOLOMON and J.H. WOODS, Narcotic discrimination in pigeons." Antagonism by naltrexone, European J. Pharmacol. 105 (1984) 137-142. In pigeons trained to discriminate between morphine (10 mg/kg) and saline, both morphine and ethylketazocine produced dose-related morphine-appropriate responding. The maximum effect produced by meperidine, however, was only 60% of th...

Interviews were conducted with 265 orthopedic and chronic pain patients, using a structured diagnostic instrument (ADDIS/SUDDS) concerning their use of analgesics. Twenty-two percent of the patients met criteria for analgesic use disorders in accordance with DSM-III-R; 18.5% fulfilled DSM-IV criteria. Dextropropoxyphene was the most common analgesic prescribed and was used by 47% of the patient...

Introduction: We previously reported a case using caudal morphine for pediatric liver transplantation. A 3-yr-old, 14.9 kg child received a caudal injection of 0.6 mg of preservative free morphine sulfate as well as 110 mcg of intravenous fentanyl. Also, the surgical incisions were infiltrated with 20 ml of 0.125% bupivacaine1. However, a question arose as to the impact of the local anesthetic ...

It has been reported! by Simon 1) that several synthetic analogs of the morphine series are strong inhibitors of bacterial growth. Simon attributes this effect to selective inhibition of ribosomal RNA synthesis (2, 3). We have studied the effects of the most potent of these drugs, levallorphan tartrate, on macromolecular synthesis in Escherichia coli. This d!rug was selected for study because i...

The treatment of pain in acute myocardial infarction varies with local practice. Narcotic analgesics are still the usual treatment in many hospitals. Knowledge of optimal doses, duration of pain relief, and time between drug administration and pain relief is inadequate. Many studies indicate that the relief of pain is often incomplete after' treatment with narcotic analgesics. There is often a ...